Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 233287..233806 Replicon chromosome
Accession NC_009778
Organism Cronobacter sakazakii ATCC BAA-894

Toxin (Protein)


Gene name relE Uniprot ID A0A6L3SA96
Locus tag ESA_RS01160 Protein ID WP_012123737.1
Coordinates 233519..233806 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6L3PAY9
Locus tag ESA_RS01155 Protein ID WP_012123736.1
Coordinates 233287..233529 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESA_RS01140 229330..230448 + 1119 WP_041460366.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
ESA_RS01145 230445..231185 + 741 WP_012123734.1 KDGP aldolase family protein -
ESA_RS01150 231299..233209 + 1911 WP_012123735.1 BglG family transcription antiterminator -
ESA_RS01155 233287..233529 + 243 WP_012123736.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ESA_RS01160 233519..233806 + 288 WP_012123737.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ESA_RS01165 233814..234278 - 465 WP_007897806.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ESA_RS01170 234574..236709 - 2136 WP_012123738.1 anaerobic ribonucleoside-triphosphate reductase -
ESA_RS01175 237006..237887 - 882 WP_012123739.1 LysR family transcriptional regulator -
ESA_RS01180 237990..238520 + 531 WP_012123740.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10839.85 Da        Isoelectric Point: 10.5836

>T22359 WP_012123737.1 NC_009778:233519-233806 [Cronobacter sakazakii ATCC BAA-894]
MSYKLVFDPRALKEWHKLGETVKAQFKKKLAHVLAAPRVKSVRLSGLPDCYKIKLRTSGYRLVYQVRDDAVCVLVIAIGK
RENLTVYQGAGHRLE

Download         Length: 288 bp

>T22359 NC_009778:233519-233806 [Cronobacter sakazakii ATCC BAA-894]
ATGAGCTATAAACTGGTCTTTGACCCACGTGCGCTGAAGGAGTGGCACAAACTGGGCGAGACCGTTAAAGCGCAATTCAA
AAAGAAGCTGGCGCACGTGCTGGCGGCTCCCAGGGTGAAATCCGTCCGGTTAAGTGGCCTGCCGGACTGCTACAAAATTA
AATTAAGAACGAGCGGTTACCGGCTGGTGTATCAGGTGCGCGATGATGCTGTCTGTGTGCTGGTCATCGCGATCGGCAAA
CGCGAAAACCTGACCGTATACCAGGGGGCCGGGCACCGTCTGGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9068.47 Da        Isoelectric Point: 5.1088

>AT22359 WP_012123736.1 NC_009778:233287-233529 [Cronobacter sakazakii ATCC BAA-894]
MATINVRLDDKLKNEAYAVLEKLGITPTEAVRLLFQYVAQNGRMPVKTLTVSDSEEALLRTVRERLADPRQGIRVDLDEL

Download         Length: 243 bp

>AT22359 NC_009778:233287-233529 [Cronobacter sakazakii ATCC BAA-894]
ATGGCCACAATCAACGTAAGGCTTGATGACAAGCTTAAAAATGAGGCTTATGCGGTGCTGGAAAAACTGGGTATCACACC
TACCGAAGCGGTGCGTCTGCTGTTTCAGTATGTGGCGCAAAATGGCCGTATGCCGGTCAAAACGCTAACCGTCAGCGACA
GCGAAGAGGCGCTGCTGCGTACCGTGCGGGAGCGACTGGCGGACCCGCGACAGGGCATCAGGGTTGATCTGGATGAGCTA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L3SA96

Antitoxin

Source ID Structure
AlphaFold DB A0A6L3PAY9

References