Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 67557..68158 | Replicon | plasmid pEc-050-T5-ESBL_3 |
| Accession | NZ_CP086493 | ||
| Organism | Escherichia coli strain Ec-050-T5-ESBL | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | LNN51_RS24975 | Protein ID | WP_168420618.1 |
| Coordinates | 67778..68158 (+) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | LNN51_RS24970 | Protein ID | WP_001190712.1 |
| Coordinates | 67557..67778 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNN51_RS24910 (LNN51_24915) | 62979..63173 | + | 195 | WP_000224731.1 | hypothetical protein | - |
| LNN51_RS24915 (LNN51_24920) | 63175..63384 | + | 210 | WP_000951710.1 | hypothetical protein | - |
| LNN51_RS24920 (LNN51_24925) | 63381..63506 | + | 126 | Protein_81 | DUF551 domain-containing protein | - |
| LNN51_RS24925 (LNN51_24930) | 64017..64208 | + | 192 | WP_242806062.1 | DUF551 domain-containing protein | - |
| LNN51_RS24930 (LNN51_24935) | 64201..64482 | + | 282 | WP_102218741.1 | ASCH domain-containing protein | - |
| LNN51_RS24935 (LNN51_24940) | 64475..64879 | + | 405 | WP_080077662.1 | hypothetical protein | - |
| LNN51_RS24940 (LNN51_24945) | 64892..65185 | + | 294 | WP_075660654.1 | hypothetical protein | - |
| LNN51_RS24945 (LNN51_24950) | 65185..65361 | + | 177 | WP_157902266.1 | hypothetical protein | - |
| LNN51_RS24950 (LNN51_24955) | 65441..65650 | + | 210 | WP_075660655.1 | hypothetical protein | - |
| LNN51_RS24955 (LNN51_24960) | 65647..66405 | + | 759 | WP_072756859.1 | hypothetical protein | - |
| LNN51_RS24960 (LNN51_24965) | 66720..66971 | + | 252 | WP_063074807.1 | DNA polymerase III subunit theta | - |
| LNN51_RS24965 (LNN51_24970) | 67095..67484 | + | 390 | WP_168420616.1 | S24 family peptidase | - |
| LNN51_RS24970 (LNN51_24975) | 67557..67778 | + | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LNN51_RS24975 (LNN51_24980) | 67778..68158 | + | 381 | WP_168420618.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| LNN51_RS24980 (LNN51_24985) | 68242..69042 | - | 801 | WP_168420620.1 | hypothetical protein | - |
| LNN51_RS24985 (LNN51_24990) | 69049..69711 | - | 663 | WP_168420622.1 | DUF2829 domain-containing protein | - |
| LNN51_RS24990 (LNN51_24995) | 69726..70220 | - | 495 | WP_000640906.1 | dUTP diphosphatase | - |
| LNN51_RS24995 (LNN51_25000) | 70217..70693 | - | 477 | WP_000861174.1 | hypothetical protein | - |
| LNN51_RS25000 (LNN51_25005) | 70690..71034 | - | 345 | WP_001191776.1 | hypothetical protein | - |
| LNN51_RS25005 (LNN51_25010) | 71108..72136 | - | 1029 | WP_168420624.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..89996 | 89996 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13605.50 Da Isoelectric Point: 5.6406
>T223573 WP_168420618.1 NZ_CP086493:67778-68158 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPVLVELAVGAATGEIPVSSVAEKLRELFGSNI
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPVLVELAVGAATGEIPVSSVAEKLRELFGSNI
Download Length: 381 bp
>T223573 NZ_CP118964:202901-203194 [Acinetobacter lwoffii]
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA
ATGACTTATAAGCTTTTACGTCACAAGGACTTTACAGCAGAATGGGAAAAACTCCCTGTTGCTATACGAGATCAATTTAA
AAAGAAACTAGCCAAAGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGCGATCTTGCAGGTTGCTATAAAA
TCAAATTATTAAAAGCTGGTGTCCGACTTGTCTATCAAGTTAAAGATGATCAGGTAGTTATCCTGCTCATTACCGTCGGA
AAACGAGCTGATAGCATAGTTTATGACGAAGCGAAAAAGCGAATTAAAGACTAA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT223573 WP_001190712.1 NZ_CP086493:67557-67778 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT223573 NZ_CP118964:202666-202911 [Acinetobacter lwoffii]
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGATGAAGAATTATTAGCTCTTGTTCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA
ATGGCTACTGTTAACTTCAGGATCGATGAAGCCCTTAAAGAAAAATCTTATTCAATCCTTAAAGAGCAAGGTATTGCACC
TACGGATTTCTTCACTAGTATTCTTGAGTATGTTGCTACGACTGGGAAACTGCCTGTCAAAAAAGCTTTGCTTTCAGAAG
AAGATGAAGAATTATTAGCTCTTGTTCGTAAGCGCATTAATGATCCTAAAGAGATGTTTGAGGAAGTCACATTAGATGAC
TTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|