Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3573597..3574215 Replicon chromosome
Accession NZ_CP086490
Organism Escherichia coli strain Ec-050-T5-ESBL

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LNN51_RS17170 Protein ID WP_001291435.1
Coordinates 3573997..3574215 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LNN51_RS17165 Protein ID WP_000344800.1
Coordinates 3573597..3573971 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN51_RS17155 (3568686) 3568686..3569879 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LNN51_RS17160 (3569902) 3569902..3573051 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LNN51_RS17165 (3573597) 3573597..3573971 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LNN51_RS17170 (3573997) 3573997..3574215 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LNN51_RS17175 (3574387) 3574387..3574938 + 552 WP_000102564.1 maltose O-acetyltransferase -
LNN51_RS17180 (3575054) 3575054..3575524 + 471 WP_000136192.1 YlaC family protein -
LNN51_RS17185 (3575688) 3575688..3577238 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LNN51_RS17190 (3577280) 3577280..3577633 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LNN51_RS17200 (3578012) 3578012..3578323 + 312 WP_000409911.1 MGMT family protein -
LNN51_RS17205 (3578354) 3578354..3578926 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T223555 WP_001291435.1 NZ_CP086490:3573997-3574215 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T223555 NZ_CP118962:c312535-312440 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAGTTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT223555 WP_000344800.1 NZ_CP086490:3573597-3573971 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT223555 NZ_CP118962:312341-312405 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGCGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References