Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1920512..1921347 Replicon chromosome
Accession NZ_CP086490
Organism Escherichia coli strain Ec-050-T5-ESBL

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag LNN51_RS09205 Protein ID WP_042046912.1
Coordinates 1920512..1920889 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag LNN51_RS09210 Protein ID WP_135145692.1
Coordinates 1920979..1921347 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN51_RS09170 (1916032) 1916032..1916505 + 474 WP_001105407.1 DNA gyrase inhibitor SbmC -
LNN51_RS09175 (1916703) 1916703..1917761 + 1059 WP_001200895.1 FUSC family protein -
LNN51_RS09180 (1917933) 1917933..1918262 + 330 WP_000450409.1 DUF496 family protein -
LNN51_RS09185 (1918363) 1918363..1918728 - 366 WP_001280455.1 EutP/PduV family microcompartment system protein -
LNN51_RS09190 (1918999) 1918999..1919388 - 390 WP_077875581.1 transposase -
LNN51_RS09195 (1920186) 1920186..1920266 - 81 Protein_1812 hypothetical protein -
LNN51_RS09200 (1920366) 1920366..1920515 - 150 Protein_1813 DUF5983 family protein -
LNN51_RS09205 (1920512) 1920512..1920889 - 378 WP_042046912.1 TA system toxin CbtA family protein Toxin
LNN51_RS09210 (1920979) 1920979..1921347 - 369 WP_135145692.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LNN51_RS09215 (1921510) 1921510..1921731 - 222 WP_000692345.1 DUF987 domain-containing protein -
LNN51_RS09220 (1921794) 1921794..1921874 - 81 Protein_1817 JAB domain-containing protein -
LNN51_RS09225 (1921961) 1921961..1922707 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
LNN51_RS09230 (1922722) 1922722..1924263 - 1542 WP_002431311.1 IS21-like element ISEc12 family transposase -
LNN51_RS09235 (1924455) 1924455..1924856 - 402 Protein_1820 JAB domain-containing protein -
LNN51_RS09240 (1924872) 1924872..1925345 - 474 WP_000855059.1 antirestriction protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14020.96 Da        Isoelectric Point: 7.8276

>T223544 WP_042046912.1 NZ_CP086490:c1920889-1920512 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T223544 NZ_CP118942:c3424312-3423011 [Aeromonas hydrophila]
ATGAACGGCTACCGGGTGGGTACCTTTACCAAGACAACCAGCGGTGCCCACCAATTTCAGTACGATGAGTCTTGGATGAA
GCAGCCAGGCAGCCGCCCCATCTCGCTCTCAATGCCATTACGCCAGCAGTGCTATCGGGGCGATGAGACATATAACTTTT
TCGGAAACTTGTTGCCGGATAATCCGGAAGTGAGAAACCGGGTGGTGGCGCGCTATCAGGCAGTCTCCACCCAGCCCTTT
GACCTACTCAGTTGTATTGGTCAGGACAGCGTGGGGGCATTGCAACTGGTGGCCCAGGGTGGCCCTGTACCAGACGTCAG
ACGCATCAAGTGTAAACCTCTCTCTGATGTTGAACTGGAGCAGATCCTGACCAGCTATCAGCAAGGGATACCTCTTGGGA
TGATCAGGGAAGTGGAGGATTTTCGGATCTCTATCGCCGGGGCGCAGGAAAAGACTGCGCTACTCTATCGCGACAACCGC
TGGTACTTACCAAGCGCGGCGACCCCAACCACCCATATCATTAAGTTGCCTATTGGTAAGATCGAGAGCCACTCCTACTC
GATAGATCTCTCCCAGAGCGTGGAGAACGAGTATCTCTGTACCCTGATAGCTAAAGAGTTTGGTCTTCCCGTCCCCCATT
GCTTCATCATGCAGGTAGGCAAGATCAAGGCTTTGGCAGTGGAGCGCTTCGATCGACGCTACGCCGCTGATCGAAGTTGG
ATCATGCGTCTGCCCCAGGAGGATTTCTGCCAGGTGTTGAATGTACCGTCAGCACGGAAGTACGAGAACCATGGTGGGCC
GAGTATTGCTGACATCATGACGACCCTGTTGGGGTCTGCCACACCGGAGCAGGATCGTTACCTGTTTATGAAGTCTCAAG
TGCTGTTCTGGCTGCTGGCAGCGACTGACGGTCATGCAAAGAACTTCTCGGTCTTTATAGAACCGGGGGGAAGCTTCCGA
CTGACACCATTTTACGACATTCTCTCTATGTATCCCGCATTTGGTGGTAGAGGGCTACATCCTCGCGATGCCAAACTGGC
CATGGGACTTACCTCAATCAAAGGCAAGGAATACGCGATAGAGCTGATATTTCCTCGCCATTTCTACCAGACGGCCAAGG
CCGTTGGCTTTGAACAGGCGCAGATGGAACGGATTATCGTTGAGTTCATCAGTAATATTGAGGCGGTGATATCGAAAGTT
CGCGCGCAGCTGCCCGCTACATTTCCCACTCTGATTGCGGAGTCAATATTGAACGGACTCAGTGCCAGAGCCCAACGTTT
TGCTCGCCCACCAACCGAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13545.30 Da        Isoelectric Point: 6.4764

>AT223544 WP_135145692.1 NZ_CP086490:c1921347-1920979 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPHHQHTVTLYAKGLTCEADTLGSCGYAYLAVYPTPETKK

Download         Length: 369 bp

>AT223544 NZ_CP118942:c3424587-3424333 [Aeromonas hydrophila]
ATGAAAGTAACCAGCGCGAAGCAGCTTAGTGCCTGCATCAAAGATGCTAGGCTTTTGCAAAAACATTCTCAGGGCAAGGT
TGCAGACAAGGTTGGCATCAGACAAGACACCGTCTCCAATTTTGAGCTCAATCCAGAATCAACCAAGCTGGATACCTTGT
TCAAAATCCTCGCCGCGTTGGAACTATCCCTCGATATCAAGCCTCGCACCGATCCATCGGATAGCCCTTCGTCAGGCTGG
AAAGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References