Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 41197..41798 | Replicon | plasmid pEc-050-T20-MAC_3 |
| Accession | NZ_CP086483 | ||
| Organism | Escherichia coli strain Ec-050-T20-MAC | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | LNN46_RS24860 | Protein ID | WP_168420618.1 |
| Coordinates | 41418..41798 (+) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | LNN46_RS24855 | Protein ID | WP_001190712.1 |
| Coordinates | 41197..41418 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LNN46_RS24795 (LNN46_24800) | 36619..36813 | + | 195 | WP_000224731.1 | hypothetical protein | - |
| LNN46_RS24800 (LNN46_24805) | 36815..37024 | + | 210 | WP_000951710.1 | hypothetical protein | - |
| LNN46_RS24805 (LNN46_24810) | 37021..37146 | + | 126 | Protein_54 | DUF551 domain-containing protein | - |
| LNN46_RS24810 (LNN46_24815) | 37657..37848 | + | 192 | WP_242806062.1 | DUF551 domain-containing protein | - |
| LNN46_RS24815 (LNN46_24820) | 37841..38122 | + | 282 | WP_102218741.1 | ASCH domain-containing protein | - |
| LNN46_RS24820 (LNN46_24825) | 38115..38519 | + | 405 | WP_080077662.1 | hypothetical protein | - |
| LNN46_RS24825 (LNN46_24830) | 38532..38825 | + | 294 | WP_075660654.1 | hypothetical protein | - |
| LNN46_RS24830 (LNN46_24835) | 38825..39001 | + | 177 | WP_157902266.1 | hypothetical protein | - |
| LNN46_RS24835 (LNN46_24840) | 39081..39290 | + | 210 | WP_075660655.1 | hypothetical protein | - |
| LNN46_RS24840 (LNN46_24845) | 39287..40045 | + | 759 | WP_072756859.1 | hypothetical protein | - |
| LNN46_RS24845 (LNN46_24850) | 40360..40611 | + | 252 | WP_063074807.1 | DNA polymerase III subunit theta | - |
| LNN46_RS24850 (LNN46_24855) | 40735..41124 | + | 390 | WP_168420616.1 | S24 family peptidase | - |
| LNN46_RS24855 (LNN46_24860) | 41197..41418 | + | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LNN46_RS24860 (LNN46_24865) | 41418..41798 | + | 381 | WP_168420618.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| LNN46_RS24865 (LNN46_24870) | 41882..42682 | - | 801 | WP_168420620.1 | hypothetical protein | - |
| LNN46_RS24870 (LNN46_24875) | 42689..43351 | - | 663 | WP_168420622.1 | DUF2829 domain-containing protein | - |
| LNN46_RS24875 (LNN46_24880) | 43366..43860 | - | 495 | WP_000640906.1 | dUTP diphosphatase | - |
| LNN46_RS24880 (LNN46_24885) | 43857..44333 | - | 477 | WP_000861174.1 | hypothetical protein | - |
| LNN46_RS24885 (LNN46_24890) | 44330..44674 | - | 345 | WP_001191776.1 | hypothetical protein | - |
| LNN46_RS24890 (LNN46_24895) | 44748..45776 | - | 1029 | WP_168420624.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..89996 | 89996 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13605.50 Da Isoelectric Point: 5.6406
>T223531 WP_168420618.1 NZ_CP086483:41418-41798 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPVLVELAVGAATGEIPVSSVAEKLRELFGSNI
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPVLVELAVGAATGEIPVSSVAEKLRELFGSNI
Download Length: 381 bp
>T223531 NZ_CP118937:44815-45297 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT223531 WP_001190712.1 NZ_CP086483:41197-41418 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT223531 NZ_CP118937:44561-44827 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|