Detailed information of TA system TA022352

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2341247..2342940
• Replicon: chromosome
• Accession: NC_009719
• Organism: Parvibaculum lavamentivorans DS-1

Toxin (Protein)

• Gene name: HipA2
• Uniprot ID: A7HV41
• Locus tag: PLAV_RS10935
• Protein ID: WP_012111079.1
• Coordinates: 2341247..2342596 (-)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: HipB2
• Uniprot ID: -
• Locus tag: PLAV_RS19355
• Protein ID: WP_143710207.1
• Coordinates: 2342593..2342940 (-)
• Length: 116 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLAV_RS10910	2337259..2337675	+	417	WP_012111074.1	nuclear transport factor 2 family protein	-
PLAV_RS10915	2337761..2338417	+	657	WP_012111075.1	peptide-methionine (S)-S-oxide reductase MsrA	-
PLAV_RS10920	2338414..2338761	-	348	WP_012111076.1	hypothetical protein	-
PLAV_RS10925	2338837..2339970	-	1134	WP_168713194.1	AI-2E family transporter	-
PLAV_RS10930	2340055..2341041	-	987	WP_143710206.1	RNA polymerase sigma factor RpoH	-
PLAV_RS10935	2341247..2342596	-	1350	WP_012111079.1	HipA domain-containing protein	Toxin
PLAV_RS19355	2342593..2342940	-	348	WP_143710207.1	helix-turn-helix transcriptional regulator	Antitoxin
PLAV_RS10945	2343067..2343390	-	324	WP_012111081.1	transcriptional regulator	-
PLAV_RS10950	2343868..2344971	-	1104	WP_041535960.1	RluA family pseudouridine synthase	-
PLAV_RS10955	2344970..2345356	+	387	WP_041535961.1	hypothetical protein	-
PLAV_RS10965	2346199..2346927	-	729	WP_012111084.1	FkbM family methyltransferase	-
PLAV_RS10970	2346947..2347357	-	411	WP_012111085.1	MAPEG family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (16-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (60-110)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 49142.11 Da
• Isoelectric Point: 5.2533

>T22352 WP_012111079.1 NC_009719:c2342596-2341247 [Parvibaculum lavamentivorans DS-1]
MSAAQPDILDVRLEAADIPLGHLARKDGGCRFAYTPDYLARTDAMPLSLSLPLREEPYGDVESRAFFDNLLQENDQLQQT
MDRERIARDDIVGLLSFVGGDCAGAISCLPPGSGPVKVPGNLATDYDELPREELIDIMRRLADKLPLPDAIKDPSPVAGV
QRKIALTEIAKGRFGLPKPGLRVPTTHILKVPERRLAREVLLEAVATRLAHAVGLEVAIPAEFKLDDEAGLLSLRFDRRI
DVNSVTRIHQEDFCQALGLPARLKYERNGTAELRFAATAVSDLLGRTAAPARDKRSFMVSAFFNLAIGNNDNHAKNHALL
YDTGPIPRLAPLYDLQPVRLTGRYTDELAFRIGAADRFDTVTAGDIAAFMAAFGPGTATAQRRFIEGEVGPMLAELDRQT
AVLPSHGLKDFDDLIGREISQLADLLGLKLATRERDYFTEKGGGWGQLS

Nucleotide

• Length: 1350 bp

>T22352 NC_009719:c2342596-2341247 [Parvibaculum lavamentivorans DS-1]
ATGAGTGCCGCACAGCCCGACATTCTGGACGTGCGCTTGGAAGCCGCCGACATTCCACTCGGGCATCTGGCGCGCAAGGA
TGGCGGCTGCCGCTTCGCTTATACGCCAGACTATCTCGCGCGCACCGACGCCATGCCGCTCTCGTTGTCCCTGCCGCTGC
GCGAGGAACCTTACGGCGATGTCGAGTCACGCGCCTTTTTCGACAACCTGCTACAGGAAAACGATCAGCTTCAGCAGACG
ATGGACCGCGAACGTATCGCCCGCGACGACATTGTCGGCCTGCTGAGTTTTGTCGGCGGCGACTGCGCGGGCGCGATCAG
TTGCCTGCCGCCGGGAAGCGGCCCGGTCAAGGTTCCGGGTAACCTCGCCACGGATTACGACGAACTGCCGCGCGAGGAAC
TCATCGATATCATGCGCCGCCTCGCAGACAAGTTGCCCTTACCGGACGCCATAAAAGACCCGTCGCCGGTTGCAGGCGTG
CAGCGCAAGATCGCGCTGACAGAAATCGCGAAGGGCCGTTTCGGCCTGCCGAAGCCCGGCCTGCGCGTGCCGACGACGCA
TATATTGAAGGTGCCGGAGCGCCGACTGGCACGCGAAGTGTTGCTGGAAGCCGTTGCCACGCGACTGGCGCATGCCGTGG
GGCTCGAGGTCGCCATACCGGCGGAATTCAAACTCGACGACGAAGCCGGCTTGTTGAGCTTGCGCTTCGACCGCCGCATC
GACGTCAATAGCGTGACGCGCATCCACCAGGAAGATTTCTGTCAGGCATTGGGCCTGCCTGCTCGCCTCAAATATGAGCG
CAACGGAACGGCAGAATTGCGCTTCGCGGCCACCGCCGTTTCAGACCTGCTCGGCCGCACCGCCGCGCCGGCAAGAGACA
AGCGCAGCTTCATGGTGTCGGCGTTTTTCAATCTCGCGATCGGCAATAACGACAATCACGCGAAGAACCATGCGCTGCTT
TACGACACGGGGCCTATACCGCGCCTTGCGCCGCTTTACGACCTGCAACCCGTGCGGCTGACCGGGCGCTATACCGACGA
GCTGGCCTTCAGGATCGGCGCCGCCGACCGCTTCGACACGGTGACGGCGGGCGACATCGCCGCTTTCATGGCGGCTTTCG
GGCCGGGCACGGCGACGGCGCAGCGGCGCTTCATCGAGGGTGAAGTCGGGCCGATGCTGGCGGAGCTGGACAGGCAGACG
GCTGTGCTGCCTTCGCATGGATTGAAGGATTTCGACGATCTGATCGGCCGCGAAATCTCGCAGCTTGCGGACCTGCTTGG
GCTCAAGCTGGCGACCAGGGAGCGGGACTATTTCACGGAAAAGGGCGGCGGCTGGGGACAATTGAGCTGA

Antitoxin

Protein

• Length: 116 a.a.
• Molecular weight: 12212.12 Da
• Isoelectric Point: 10.7464

>AT22352 WP_143710207.1 NC_009719:c2342940-2342593 [Parvibaculum lavamentivorans DS-1]
MTSRGRKTGRAGLLDDLAVTSVATASPAPLAELLAPLATSTSPKPETPIQSFRNLGDLVRTARITKDLSQQELADMAGVG
RRFVSELENGKATLEIGRVLKVCQALGVDLVARKR

Nucleotide

• Length: 348 bp

>AT22352 NC_009719:c2342940-2342593 [Parvibaculum lavamentivorans DS-1]
ATGACAAGCCGCGGCAGGAAGACCGGGAGAGCAGGATTGCTGGACGACCTCGCCGTTACAAGCGTGGCGACCGCCTCCCC
CGCCCCCTTGGCCGAACTCCTGGCCCCGCTGGCAACGTCCACAAGCCCGAAGCCCGAAACCCCAATCCAGTCGTTCAGGA
ATCTTGGCGATCTCGTCAGAACCGCCCGCATCACCAAAGACCTCTCCCAGCAAGAACTGGCCGACATGGCGGGTGTGGGC
CGGCGTTTCGTGTCGGAACTGGAAAACGGCAAGGCGACGCTCGAAATAGGACGTGTACTGAAGGTGTGTCAGGCGCTCGG
CGTCGACCTTGTGGCGCGCAAGCGATGA

Structures

Toxin

• AlphaFold DB: A7HV41