Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3573596..3574214 Replicon chromosome
Accession NZ_CP086480
Organism Escherichia coli strain Ec-050-T20-MAC

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag LNN46_RS17180 Protein ID WP_001291435.1
Coordinates 3573996..3574214 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag LNN46_RS17175 Protein ID WP_000344800.1
Coordinates 3573596..3573970 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN46_RS17165 (3568685) 3568685..3569878 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LNN46_RS17170 (3569901) 3569901..3573050 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
LNN46_RS17175 (3573596) 3573596..3573970 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
LNN46_RS17180 (3573996) 3573996..3574214 + 219 WP_001291435.1 HHA domain-containing protein Toxin
LNN46_RS17185 (3574386) 3574386..3574937 + 552 WP_000102564.1 maltose O-acetyltransferase -
LNN46_RS17190 (3575053) 3575053..3575523 + 471 WP_000136192.1 YlaC family protein -
LNN46_RS17195 (3575687) 3575687..3577237 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
LNN46_RS17200 (3577279) 3577279..3577632 - 354 WP_000878140.1 DUF1428 domain-containing protein -
LNN46_RS17210 (3578011) 3578011..3578322 + 312 WP_000409911.1 MGMT family protein -
LNN46_RS17215 (3578353) 3578353..3578925 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T223513 WP_001291435.1 NZ_CP086480:3573996-3574214 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T223513 NZ_CP118932:1928961-1929057 [Serratia marcescens]
AACAAGCCCTGCATTAAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATAGGAATC
GTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT223513 WP_000344800.1 NZ_CP086480:3573596-3573970 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT223513 NZ_CP118932:c1929057-1928917 [Serratia marcescens]
AAAAAAAGACCGAATACGATTCCTATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCAT
TTAATGCAGGGCTTGTTCAGCCGTGCACTTTAAGAGTAGCCTACCGCGCCAGTTTTGCCAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References