Detailed information of TA system TA022349

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1752237..1752726
• Replicon: chromosome
• Accession: NC_009719
• Organism: Parvibaculum lavamentivorans DS-1

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: A7HTK3
• Locus tag: PLAV_RS08185
• Protein ID: WP_012110524.1
• Coordinates: 1752448..1752726 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A7HTK2
• Locus tag: PLAV_RS08180
• Protein ID: WP_012110523.1
• Coordinates: 1752237..1752464 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLAV_RS08160	1747939..1748130	-	192	WP_012110519.1	twin transmembrane helix small protein	-
PLAV_RS08165	1748130..1749836	-	1707	WP_012110520.1	acyl-CoA dehydrogenase family protein	-
PLAV_RS08170	1750043..1751515	+	1473	WP_012110521.1	TrkH family potassium uptake protein	-
PLAV_RS08175	1751522..1752094	-	573	WP_012110522.1	hypothetical protein	-
PLAV_RS08180	1752237..1752464	+	228	WP_012110523.1	ribbon-helix-helix protein, CopG family	Antitoxin
PLAV_RS08185	1752448..1752726	+	279	WP_012110524.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PLAV_RS08190	1752733..1753623	-	891	WP_012110525.1	MBL fold metallo-hydrolase	-
PLAV_RS08195	1753746..1754057	+	312	WP_012110526.1	metalloregulator ArsR/SmtB family transcription factor	-
PLAV_RS08200	1754092..1754613	+	522	WP_012110527.1	rhodanese family protein	-
PLAV_RS08205	1754624..1755889	-	1266	WP_012110528.1	crotonyl-CoA carboxylase/reductase	-
PLAV_RS08210	1756080..1757180	+	1101	WP_012110529.1	ferritin-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10802.45 Da
• Isoelectric Point: 10.0948

>T22349 WP_012110524.1 NC_009719:1752448-1752726 [Parvibaculum lavamentivorans DS-1]
MAWTIDYTDDAINQLRKLDKQSARRIVEYMDERIAGAANPRSFGKPLSGPLGQFWRYRVGDFRIICDIEDEVLRVLVVRI
GDRKDVYRKAKR

Nucleotide

• Length: 279 bp

>T22349 NC_009719:1752448-1752726 [Parvibaculum lavamentivorans DS-1]
TTGGCCTGGACGATTGATTATACCGACGACGCCATAAACCAGCTTCGCAAGCTCGACAAGCAATCGGCGCGGCGCATCGT
CGAGTATATGGACGAACGCATTGCCGGCGCAGCCAACCCGCGCAGCTTCGGCAAGCCGCTCTCGGGTCCGCTCGGCCAGT
TCTGGCGCTACCGCGTCGGCGACTTCCGGATCATCTGCGACATCGAAGATGAAGTGCTGCGCGTGTTGGTCGTCCGCATC
GGCGACAGGAAAGACGTCTACCGCAAGGCAAAGCGGTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8667.86 Da
• Isoelectric Point: 5.2065

>AT22349 WP_012110523.1 NC_009719:1752237-1752464 [Parvibaculum lavamentivorans DS-1]
MPTSVRLDAELEARLDLLAKKTGRTRAYYLREIIERGLDEMEDYYLAADVLERVRKGEEKTHSAAKVRKDLGLDD

Nucleotide

• Length: 228 bp

>AT22349 NC_009719:1752237-1752464 [Parvibaculum lavamentivorans DS-1]
ATGCCCACCTCTGTCCGCCTCGATGCAGAACTGGAAGCGCGTCTCGATCTTCTCGCGAAGAAGACGGGGCGCACCCGCGC
CTATTATCTGCGCGAGATCATCGAGCGGGGGCTCGACGAGATGGAAGACTATTATCTCGCCGCCGACGTGCTGGAGCGTG
TCCGCAAGGGCGAGGAAAAAACGCATTCCGCGGCCAAGGTGAGAAAAGACCTTGGCCTGGACGATTGA

Structures

Toxin

• AlphaFold DB: A7HTK3

Antitoxin

• AlphaFold DB: A7HTK2