Detailed information of TA system TA022347

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 1149284..1149829
• Replicon: chromosome
• Accession: NC_009719
• Organism: Parvibaculum lavamentivorans DS-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: PLAV_RS05330
• Protein ID: WP_041535862.1
• Coordinates: 1149536..1149829 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A7HRY5
• Locus tag: PLAV_RS05325
• Protein ID: WP_012109924.1
• Coordinates: 1149284..1149526 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PLAV_RS05300	1144784..1145974	+	1191	WP_143710287.1	SIR2 family protein	-
PLAV_RS05305	1145974..1147998	+	2025	WP_012109922.1	DUF87 domain-containing protein	-
PLAV_RS18770	1148000..1149187	+	1188	WP_012109923.1	hypothetical protein	-
PLAV_RS05325	1149284..1149526	+	243	WP_012109924.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
PLAV_RS05330	1149536..1149829	+	294	WP_041535862.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PLAV_RS05335	1150159..1153146	+	2988	WP_012109926.1	AAA family ATPase	-
PLAV_RS05340	1153403..1154545	-	1143	WP_012109927.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-92)

Antitoxin

• Antitoxin ParD (3-70)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11197.79 Da
• Isoelectric Point: 5.5687

>T22347 WP_041535862.1 NC_009719:1149536-1149829 [Parvibaculum lavamentivorans DS-1]
MVYRLARKAEEDIITVYQQGVVLFGAAQAETYHARLEQAFDFLSANPRAARERLEITPPVRCHPLGVHIIIYLIEENDDV
LILRVRHSREDWDASPI

Nucleotide

• Length: 294 bp

>T22347 NC_009719:1149536-1149829 [Parvibaculum lavamentivorans DS-1]
ATGGTATATAGACTCGCCCGCAAGGCAGAAGAAGACATCATCACGGTATATCAGCAAGGTGTAGTGCTGTTCGGCGCTGC
TCAGGCTGAGACCTATCATGCACGGCTTGAGCAGGCGTTTGACTTTCTTTCGGCGAATCCAAGAGCCGCCAGAGAGCGCC
TGGAAATCACGCCGCCCGTCCGCTGTCATCCGCTCGGCGTTCACATCATCATTTACCTGATCGAAGAAAACGACGACGTG
CTGATATTGCGGGTGCGCCATTCCCGTGAAGATTGGGACGCCAGCCCGATCTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9157.18 Da
• Isoelectric Point: 4.7683

>AT22347 WP_012109924.1 NC_009719:1149284-1149526 [Parvibaculum lavamentivorans DS-1]
MATMNVSLPDPMKDWVEAQAETGRYSNASDYVRDLIRRDQERQDKISHMQVLVTQALESGVSDKSMDDILNEARQRATRS

Nucleotide

• Length: 243 bp

>AT22347 NC_009719:1149284-1149526 [Parvibaculum lavamentivorans DS-1]
ATGGCTACAATGAATGTATCACTCCCCGACCCTATGAAGGATTGGGTTGAAGCGCAGGCTGAGACCGGACGCTACAGCAA
TGCGAGCGACTATGTTCGCGACCTGATCCGCCGCGATCAGGAGCGGCAGGACAAGATTTCTCATATGCAGGTGCTGGTGA
CGCAAGCGCTTGAAAGCGGTGTCAGCGACAAATCTATGGACGATATTCTGAACGAAGCACGGCAACGTGCGACGCGTTCA
TAG

Structures

Antitoxin

• AlphaFold DB: A7HRY5