Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4124706..4125325 Replicon chromosome
Accession NZ_CP086467
Organism Klebsiella pneumoniae strain MCL-2017-2-T0

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LNN43_RS20320 Protein ID WP_002892050.1
Coordinates 4125107..4125325 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LNN43_RS20315 Protein ID WP_002892066.1
Coordinates 4124706..4125080 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN43_RS20305 (4119858) 4119858..4121051 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LNN43_RS20310 (4121074) 4121074..4124220 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LNN43_RS20315 (4124706) 4124706..4125080 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LNN43_RS20320 (4125107) 4125107..4125325 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LNN43_RS20325 (4125484) 4125484..4126050 + 567 WP_002892030.1 maltose O-acetyltransferase -
LNN43_RS20330 (4126022) 4126022..4126162 - 141 WP_004147370.1 hypothetical protein -
LNN43_RS20335 (4126183) 4126183..4126653 + 471 WP_002892026.1 YlaC family protein -
LNN43_RS20340 (4126628) 4126628..4128079 - 1452 WP_032435563.1 PLP-dependent aminotransferase family protein -
LNN43_RS20345 (4128180) 4128180..4128878 + 699 WP_032435564.1 GNAT family protein -
LNN43_RS20350 (4128875) 4128875..4129015 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LNN43_RS20355 (4129015) 4129015..4129278 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T223446 WP_002892050.1 NZ_CP086467:4125107-4125325 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T223446 NZ_CP118863:2333236-2333694 [Providencia rettgeri]
ATGATTTTATATCGATTGGTTAAATCCAATTTTGCGCATGATGCATGGTCGGGCCAAGGAGCTATGCTCTACGGCGGGCG
TTGGAATCATAAAGGGACTCCTGCTGTTTATACTTCAACGAGTATTTCATTAGCGACCCTTGAAATACTCGTTCACATCA
ATCAAGACAGACTATTGAGCCAGTTCAGCTTACTATCCATAGATATCAATGATAAGTACGTGATGAAATTGTCGTTAGAT
CACCTTCCGACAGATTGGCAACAAGACCCCGCACCAACCTCCACCATGGATATTGGCACTATATGGCTTAATAACCAAGA
TAGTCTAGCATTATTAATTCCCTCTTGTATTGTTCCCTATGAATACAACGCAATTATTAACCCGTTACATCCGCAATTTC
AAAAAGTTTTACATACCGTTAAACCACTAGATTTTAGTGTTGACCCGCGCTTAGCATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT223446 WP_002892066.1 NZ_CP086467:4124706-4125080 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT223446 NZ_CP118863:2332778-2333239 [Providencia rettgeri]
ATGAGAAACTATATCCCCATAACCCCACTTCAACCGACTGCTTCATCCTTTAAACCACTGTGGCGCCATGTAGGGTTACC
CGCAGAACGTGGTATTGAGTTAACTCATTTCTTGCGTCAAGGCCTATCTGTCTCTGTCTTAGACAATATCCAAGAATGGT
CAGGAATGAGCAAAACTGAATTATTGCGAATATCCGGCATTAATGAGCGCAATATTGCTCGACGCAAAAATGCTGGCCAG
CCCCTTAATGCTGATGAAAGTGAGAGAATTGCTCGTCTAGTGCGGGTATTCGATGCTGCGGTGCGTTTATTTAATGGAGA
TAAGCACGCGGCAAGTGATTGGCTTAACCACCCAGTTAAAGGGTTAGGACATTTACGCCCTATTGAGCTTATTGCGACAG
AAAGCGGAGCCATTGAAGTGATTGATTTGATTGGCCGTATTGAACATGGCGTATTCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References