Detailed information of TA system TA223436

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2309161..2310749
• Replicon: chromosome
• Accession: NZ_CP086467
• Organism: Klebsiella pneumoniae strain MCL-2017-2-T0

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A9J6RYF8
• Locus tag: LNN43_RS11260
• Protein ID: WP_004892016.1
• Coordinates: 2309427..2310749 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LNN43_RS11255
• Protein ID: WP_004176198.1
• Coordinates: 2309161..2309427 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNN43_RS11230 (2304190)	2304190..2305113	+	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-
LNN43_RS11235 (2305094)	2305094..2306248	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LNN43_RS11240 (2306594)	2306594..2307973	+	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
LNN43_RS11245 (2307951)	2307951..2308451	+	501	WP_032435339.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LNN43_RS11250 (2308448)	2308448..2308774	+	327	WP_004184023.1	hydroxyisourate hydrolase	-
LNN43_RS11255 (2309161)	2309161..2309427	+	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LNN43_RS11260 (2309427)	2309427..2310749	+	1323	WP_004892016.1	type II toxin-antitoxin system HipA family toxin	Toxin
LNN43_RS11265 (2310766)	2310766..2312058	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LNN43_RS11270 (2312200)	2312200..2313204	-	1005	WP_032435338.1	fimbrial protein	-
LNN43_RS11275 (2313192)	2313192..2315693	-	2502	WP_032435337.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49141.44 Da
• Isoelectric Point: 7.5357

>T223436 WP_004892016.1 NZ_CP086467:2309427-2310749 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T223436 NZ_CP118848:c2150330-2149959 [Mammaliicoccus lentus]
ATGAGAAGAGGAGATGTATATCTCGCAGATCTTTCTCCAGTAACTGGTTCTGAACAAGGGGGAACAAGACCAGTCGTTAT
TATACAAAATGACACAGGTAATAGATATAGTCCGACTGTTATTGTAGCAGCGATTACTGGGAAGATTAATAAAGCTAAAA
TACCTACACATGTAGAAATTGAAGCAGCGAAATATAAACTAGATAGAGATTCAGTTATTTTGCTAGAACAAATTAGAACA
ATCGATAAGAAACGGTTGAAAGAAAAATTAACATATTTATCTGATGCAAAGATGAAAGAGGTTGATTCTGCAATTGCAAT
TAGCCTCAATCTCACTTTGCAATATAAATTTGATACATTAGGTAATACATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT223436 WP_004176198.1 NZ_CP086467:2309161-2309427 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT223436 NZ_CP118848:c2150498-2150331 [Mammaliicoccus lentus]
ATGACATCGTTAACACAAAATCGCAATCAAAGTTTAGAACAAACACTGAAAGAAGGATACCGTTATATGGCTGATTTAAA
TCTCTCCCTTGCGTCTGAAGCATATTATAGTGAATGTGAAGCTTGTGATTCTAATGAGTCACACTTAACTTCTCAACAAG
GTGAATAA