Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3459529..3460149 Replicon chromosome
Accession NC_009708
Organism Yersinia pseudotuberculosis IP 31758

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag YPSIP31758_RS16710 Protein ID WP_002208622.1
Coordinates 3459946..3460149 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag YPSIP31758_RS16705 Protein ID WP_002218472.1
Coordinates 3459529..3459897 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPSIP31758_RS16690 3457724..3457984 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
YPSIP31758_RS16695 3458000..3458143 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
YPSIP31758_RS16700 3459017..3459370 + 354 WP_012105569.1 hypothetical protein -
YPSIP31758_RS16705 3459529..3459897 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
YPSIP31758_RS16710 3459946..3460149 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
YPSIP31758_RS16715 3461055..3461444 + 390 WP_002208623.1 MGMT family protein -
YPSIP31758_RS16720 3461580..3462101 - 522 WP_011191872.1 YbaY family lipoprotein -
YPSIP31758_RS16725 3462358..3463218 + 861 WP_012105571.1 acyl-CoA thioesterase II -
YPSIP31758_RS16730 3463478..3464767 - 1290 WP_002228344.1 ammonium transporter AmtB -
YPSIP31758_RS16735 3464807..3465145 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T22343 WP_002208622.1 NC_009708:3459946-3460149 [Yersinia pseudotuberculosis IP 31758]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T22343 NC_009708:3459946-3460149 [Yersinia pseudotuberculosis IP 31758]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT22343 WP_002218472.1 NC_009708:3459529-3459897 [Yersinia pseudotuberculosis IP 31758]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT22343 NC_009708:3459529-3459897 [Yersinia pseudotuberculosis IP 31758]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References