Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2309160..2310748 Replicon chromosome
Accession NZ_CP086464
Organism Klebsiella pneumoniae strain MCL-2017-2-T5-MAC

Toxin (Protein)


Gene name hipA Uniprot ID A0A9J6RYF8
Locus tag LNN59_RS11265 Protein ID WP_004892016.1
Coordinates 2309426..2310748 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LNN59_RS11260 Protein ID WP_004176198.1
Coordinates 2309160..2309426 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN59_RS11235 (2304189) 2304189..2305112 + 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -
LNN59_RS11240 (2305093) 2305093..2306247 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LNN59_RS11245 (2306593) 2306593..2307972 + 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
LNN59_RS11250 (2307950) 2307950..2308450 + 501 WP_032435339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LNN59_RS11255 (2308447) 2308447..2308773 + 327 WP_004184023.1 hydroxyisourate hydrolase -
LNN59_RS11260 (2309160) 2309160..2309426 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LNN59_RS11265 (2309426) 2309426..2310748 + 1323 WP_004892016.1 type II toxin-antitoxin system HipA family toxin Toxin
LNN59_RS11270 (2310765) 2310765..2312057 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LNN59_RS11275 (2312199) 2312199..2313203 - 1005 WP_032435338.1 fimbrial protein -
LNN59_RS11280 (2313191) 2313191..2315692 - 2502 WP_032435337.1 fimbria/pilus outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49141.44 Da        Isoelectric Point: 7.5357

>T223416 WP_004892016.1 NZ_CP086464:2309426-2310748 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T223416 NZ_CP118835:1824052-1824147 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT223416 WP_004176198.1 NZ_CP086464:2309160-2309426 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT223416 NZ_CP118835:c1824234-1824175 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References