Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5050256..5051937 Replicon chromosome
Accession NZ_CP086458
Organism Klebsiella pneumoniae strain MCL-2017-2-T20-MAC

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag LNN57_RS24745 Protein ID WP_002885155.1
Coordinates 5050256..5051173 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag LNN57_RS24750 Protein ID WP_004177809.1
Coordinates 5051179..5051937 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN57_RS24725 (5045562) 5045562..5047082 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
LNN57_RS24730 (5047079) 5047079..5048077 + 999 WP_002885172.1 ribose ABC transporter permease -
LNN57_RS24735 (5048108) 5048108..5049049 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
LNN57_RS24740 (5049124) 5049124..5050131 + 1008 WP_004177805.1 carbohydrate kinase family protein -
LNN57_RS24745 (5050256) 5050256..5051173 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LNN57_RS24750 (5051179) 5051179..5051937 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
LNN57_RS24755 (5052023) 5052023..5052751 - 729 WP_004177810.1 response regulator transcription factor -
LNN57_RS24760 (5053024) 5053024..5055171 + 2148 WP_077598921.1 formate dehydrogenase subunit alpha -
LNN57_RS24765 (5055401) 5055401..5056087 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T223390 WP_002885155.1 NZ_CP086458:c5051173-5050256 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T223390 NZ_CP118820:2035353-2035541 [Staphylococcus epidermidis]
ATGAGCTTACATTTCCAAATTTTGCTGTGGCTTTCTATCTTATTTATCATCGCAGGAACGATATTATTGGTAACAATGCT
TAAAACTAAAAGAGAAGAACGAAAAGAATCTTATCTAGGTTTTACTGTAATTTTCTTAATCTTTGGTTTTGCCATCTTAA
TTTATACTTTTATATTTGGAATTTTATAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT223390 WP_004177809.1 NZ_CP086458:c5051937-5051179 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT223390 NZ_CP118820:2035071-2035328 [Staphylococcus epidermidis]
ATGAAATTAAACAAAGCAAATGTATTCAACTTGATATTCACCATTTTATTTTTTACATTTAACATTCTCATAACCTATAA
CGCAAATGTTGATTATAAGTTATGGTTAATACCTGGTTTAGCAATTTGTGGCTTTGCTCTTTTTTCAAGCTTGACCTTAG
TAATTATCTATAGTGATTTATTCAGTGAAATATTATTTTTTATCAACATTATCTTAGCACTATATTATATTTATCCGATT
TTTTATGAATTTGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References