Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 805496..806153 Replicon chromosome
Accession NZ_CP086455
Organism Klebsiella pneumoniae strain MCL-2017-2-T20-ESBL

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LNN48_RS04030 Protein ID WP_002916310.1
Coordinates 805743..806153 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LNN48_RS04025 Protein ID WP_002916312.1
Coordinates 805496..805762 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN48_RS04000 (800704) 800704..802137 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LNN48_RS04005 (802256) 802256..802984 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LNN48_RS04010 (803034) 803034..803345 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LNN48_RS04015 (803509) 803509..804168 + 660 WP_004174454.1 hemolysin III family protein -
LNN48_RS04020 (804267) 804267..805250 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
LNN48_RS04025 (805496) 805496..805762 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LNN48_RS04030 (805743) 805743..806153 + 411 WP_002916310.1 protein YgfX Toxin
LNN48_RS04035 (806160) 806160..806681 - 522 WP_002916308.1 flavodoxin FldB -
LNN48_RS04040 (806782) 806782..807678 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LNN48_RS04045 (807701) 807701..808414 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LNN48_RS04050 (808420) 808420..810153 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T223355 WP_002916310.1 NZ_CP086455:805743-806153 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T223355 NZ_CP118755:c2611378-2611277 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT223355 WP_002916312.1 NZ_CP086455:805496-805762 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT223355 NZ_CP118755:2611153-2611332 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References