Detailed information of TA system TA223344

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2796703..2798291
• Replicon: chromosome
• Accession: NZ_CP086447
• Organism: Klebsiella pneumoniae strain AE-2247421-T0

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LNN40_RS13875
• Protein ID: WP_004184027.1
• Coordinates: 2796703..2798025 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LNN40_RS13880
• Protein ID: WP_004176198.1
• Coordinates: 2798025..2798291 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNN40_RS13860 (2791759)	2791759..2794260	+	2502	WP_032418977.1	fimbria/pilus outer membrane usher protein	-
LNN40_RS13865 (2794248)	2794248..2795252	+	1005	WP_016946380.1	fimbrial protein	-
LNN40_RS13870 (2795394)	2795394..2796686	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
LNN40_RS13875 (2796703)	2796703..2798025	-	1323	WP_004184027.1	type II toxin-antitoxin system HipA family toxin	Toxin
LNN40_RS13880 (2798025)	2798025..2798291	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LNN40_RS13885 (2798557)	2798557..2798883	-	327	WP_004215084.1	hydroxyisourate hydrolase	-
LNN40_RS13890 (2798880)	2798880..2799380	-	501	WP_032418978.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LNN40_RS13895 (2799358)	2799358..2800737	-	1380	WP_032418979.1	nucleobase:cation symporter-2 family protein	-
LNN40_RS13900 (2801083)	2801083..2802237	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
LNN40_RS13905 (2802218)	2802218..2803141	-	924	WP_032418980.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49139.47 Da
• Isoelectric Point: 7.5367

>T223344 WP_004184027.1 NZ_CP086447:c2798025-2796703 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T223344 NZ_CP118723:c4050116-4049694 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCGGTGCAGGGCGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAGGGCAAAAAGCG
CCGCCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGCATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT223344 WP_004176198.1 NZ_CP086447:c2798291-2798025 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT223344 NZ_CP118723:c4050363-4050097 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGACGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA