Detailed information of TA system TA022334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB-HicA
• Location: 2607245..2607891
• Replicon: chromosome
• Accession: NC_009708
• Organism: Yersinia pseudotuberculosis IP 31758

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A3G5L3F2
• Locus tag: YPSIP31758_RS12835
• Protein ID: WP_002214976.1
• Coordinates: 2607245..2607427 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0U1R391
• Locus tag: YPSIP31758_RS12840
• Protein ID: WP_002211129.1
• Coordinates: 2607472..2607891 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPSIP31758_RS12800	2602631..2603101	+	471	WP_002227961.1	flagellar basal body-associated protein FliL	-
YPSIP31758_RS12805	2603107..2604108	+	1002	WP_011192177.1	flagellar motor switch protein FliM	-
YPSIP31758_RS12810	2604105..2604521	+	417	WP_011192176.1	flagellar motor switch protein FliN	-
YPSIP31758_RS12815	2604521..2605057	+	537	WP_012105277.1	flagellar biosynthetic protein FliO	-
YPSIP31758_RS12820	2605138..2605878	+	741	WP_002220494.1	flagellar type III secretion system pore protein FliP	-
YPSIP31758_RS12825	2605984..2606253	+	270	WP_002211131.1	flagellar biosynthesis protein FliQ	-
YPSIP31758_RS12830	2606256..2607038	+	783	WP_011192174.1	flagellar type III secretion system protein FliR	-
YPSIP31758_RS12835	2607245..2607427	+	183	WP_002214976.1	type II toxin-antitoxin system HicA family toxin	Toxin
YPSIP31758_RS12840	2607472..2607891	+	420	WP_002211129.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
YPSIP31758_RS12845	2608151..2609110	-	960	WP_012105278.1	sugar kinase	-
YPSIP31758_RS12850	2609159..2610181	-	1023	WP_011192171.1	ABC transporter permease	-
YPSIP31758_RS12855	2610184..2611761	-	1578	WP_012105279.1	sugar ABC transporter ATP-binding protein	-
YPSIP31758_RS12860	2611827..2612822	-	996	WP_002211125.1	substrate-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-131)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6783.99 Da
• Isoelectric Point: 10.8877

>T22334 WP_002214976.1 NC_009708:2607245-2607427 [Yersinia pseudotuberculosis IP 31758]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Nucleotide

• Length: 183 bp

>T22334 NC_009708:2607245-2607427 [Yersinia pseudotuberculosis IP 31758]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15549.42 Da
• Isoelectric Point: 4.7731

>AT22334 WP_002211129.1 NC_009708:2607472-2607891 [Yersinia pseudotuberculosis IP 31758]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Nucleotide

• Length: 420 bp

>AT22334 NC_009708:2607472-2607891 [Yersinia pseudotuberculosis IP 31758]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Structures

Toxin

• AlphaFold DB: A0A3G5L3F2

Antitoxin

• AlphaFold DB: A0A0U1R391