Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2607245..2607891 Replicon chromosome
Accession NC_009708
Organism Yersinia pseudotuberculosis IP 31758

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag YPSIP31758_RS12835 Protein ID WP_002214976.1
Coordinates 2607245..2607427 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag YPSIP31758_RS12840 Protein ID WP_002211129.1
Coordinates 2607472..2607891 (+) Length 140 a.a.

Genomic Context

YPSIP31758_RS12800YPSIP31758_RS12805YPSIP31758_RS12810YPSIP31758_RS12815YPSIP31758_RS12820YPSIP31758_RS12825YPSIP31758_RS12830YPSIP31758_RS12835YPSIP31758_RS12840YPSIP31758_RS12845YPSIP31758_RS12850YPSIP31758_RS12855YPSIP31758_RS12860
Location: 2602631..2603101 (471 bp)
Type: Others
Protein ID: WP_002227961.1
Location: 2603107..2604108 (1002 bp)
Type: Others
Protein ID: WP_011192177.1
Location: 2604105..2604521 (417 bp)
Type: Others
Protein ID: WP_011192176.1
Location: 2604521..2605057 (537 bp)
Type: Others
Protein ID: WP_012105277.1
Location: 2605138..2605878 (741 bp)
Type: Others
Protein ID: WP_002220494.1
Location: 2605984..2606253 (270 bp)
Type: Others
Protein ID: WP_002211131.1
Location: 2606256..2607038 (783 bp)
Type: Others
Protein ID: WP_011192174.1
Location: 2607245..2607427 (183 bp)
Type: Toxin
Protein ID: WP_002214976.1
Location: 2607472..2607891 (420 bp)
Type: Antitoxin
Protein ID: WP_002211129.1
Location: 2608151..2609110 (960 bp)
Type: Others
Protein ID: WP_012105278.1
Location: 2609159..2610181 (1023 bp)
Type: Others
Protein ID: WP_011192171.1
Location: 2610184..2611761 (1578 bp)
Type: Others
Protein ID: WP_012105279.1
Location: 2611827..2612822 (996 bp)
Type: Others
Protein ID: WP_002211125.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
YPSIP31758_RS128002602631..2603101+471WP_002227961.1flagellar basal body-associated protein FliL-
YPSIP31758_RS128052603107..2604108+1002WP_011192177.1flagellar motor switch protein FliM-
YPSIP31758_RS128102604105..2604521+417WP_011192176.1flagellar motor switch protein FliN-
YPSIP31758_RS128152604521..2605057+537WP_012105277.1flagellar biosynthetic protein FliO-
YPSIP31758_RS128202605138..2605878+741WP_002220494.1flagellar type III secretion system pore protein FliP-
YPSIP31758_RS128252605984..2606253+270WP_002211131.1flagellar biosynthesis protein FliQ-
YPSIP31758_RS128302606256..2607038+783WP_011192174.1flagellar type III secretion system protein FliR-
YPSIP31758_RS128352607245..2607427+183WP_002214976.1type II toxin-antitoxin system HicA family toxinToxin
YPSIP31758_RS128402607472..2607891+420WP_002211129.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
YPSIP31758_RS128452608151..2609110-960WP_012105278.1sugar kinase-
YPSIP31758_RS128502609159..2610181-1023WP_011192171.1ABC transporter permease-
YPSIP31758_RS128552610184..2611761-1578WP_012105279.1sugar ABC transporter ATP-binding protein-
YPSIP31758_RS128602611827..2612822-996WP_002211125.1substrate-binding domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T22334 WP_002214976.1 NC_009708:2607245-2607427 [Yersinia pseudotuberculosis IP 31758]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T22334 NC_009708:2607245-2607427 [Yersinia pseudotuberculosis IP 31758]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT22334 WP_002211129.1 NC_009708:2607472-2607891 [Yersinia pseudotuberculosis IP 31758]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT22334 NC_009708:2607472-2607891 [Yersinia pseudotuberculosis IP 31758]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A3G5L3F2

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0U1R391

References