Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 799214..799871 Replicon chromosome
Accession NZ_CP086447
Organism Klebsiella pneumoniae strain AE-2247421-T0

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LNN40_RS03990 Protein ID WP_002916310.1
Coordinates 799461..799871 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LNN40_RS03985 Protein ID WP_002916312.1
Coordinates 799214..799480 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN40_RS03960 (794370) 794370..795803 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
LNN40_RS03965 (795922) 795922..796650 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LNN40_RS03970 (796700) 796700..797011 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LNN40_RS03975 (797175) 797175..797834 + 660 WP_002916317.1 hemolysin III family protein -
LNN40_RS03980 (797985) 797985..798968 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LNN40_RS03985 (799214) 799214..799480 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LNN40_RS03990 (799461) 799461..799871 + 411 WP_002916310.1 protein YgfX Toxin
LNN40_RS03995 (799878) 799878..800399 - 522 WP_004144730.1 flavodoxin FldB -
LNN40_RS04000 (800500) 800500..801396 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LNN40_RS04005 (801419) 801419..802132 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LNN40_RS04010 (802138) 802138..803871 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T223334 WP_002916310.1 NZ_CP086447:799461-799871 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T223334 NZ_CP118713:c2669412-2668999 [Rhizobium sp. BJ04]
ATGACGGCGTGGATGCTCGACACCAATATCGCCAGCCATGTCATCAAGGGCGATCGGCCGGAGATACTTAAAAGGCTGGC
GGCGCTTCCGATGGACGAGATCGTCATCTCATCGGTCACGGAAGGGGAGTTGCTCTACGGTCTTGCCAAGCGTGGCTATC
CGAAGGCGCTATCCGAGCGGGTCAGGCAATTCCTCCTCAGGGTCGATGTTCTCCCCTGGGATCACGACGTCACGCGAGCC
TATGGCGATCTGCGCGCTGCTTGCGAAGTCAAAGGCGTGGCTCTGGCGCCCCTCGAGATGATGATTGCCGCCCACGCCGT
CGCGACTGCCGCAACCCTCGTTACACGCGACAAGGCTTTTGCCCGCGTTTCGGAGCCTTTGAAGCTCGATGGCTGGGCGA
ATGAAGGAAGTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT223334 WP_002916312.1 NZ_CP086447:799214-799480 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT223334 NZ_CP118713:c2669672-2669409 [Rhizobium sp. BJ04]
GTGGCATCGAAAACGGCCAAGATTTTTACGACCGGCCGCAGCCAGGCGGTGCGGCTCCCTGCGGACTTCCGCTTCGAGGA
GAGCGAGGTGTTCGTTCGTCGCGATCCGAAGACCGGCGATGTCATATTATCGCGCAAGTCGGATTCATGGGATGGCCTTT
TCGAACTCCATGGGAGAGATCAGGTTCCGGACGATTTCATGGGGCCGGCCGATCGCAGCCAGCCTTCGCAGGATCATGAT
CCGTTCGAAGGCTGGAGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References