Detailed information of TA system TA022333

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2540715..2541228
• Replicon: chromosome
• Accession: NC_009708
• Organism: Yersinia pseudotuberculosis IP 31758

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A209AEM7
• Locus tag: YPSIP31758_RS12435
• Protein ID: WP_012105238.1
• Coordinates: 2540944..2541228 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A386HFF3
• Locus tag: YPSIP31758_RS12430
• Protein ID: WP_012105237.1
• Coordinates: 2540715..2540954 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPSIP31758_RS12415	2536749..2537498	-	750	WP_041175772.1	phage head morphogenesis protein	-
YPSIP31758_RS12420	2537557..2538942	-	1386	WP_012105235.1	DUF1073 domain-containing protein	-
YPSIP31758_RS12425	2538945..2540588	-	1644	WP_012105236.1	phage terminase large subunit	-
YPSIP31758_RS12430	2540715..2540954	+	240	WP_012105237.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
YPSIP31758_RS12435	2540944..2541228	+	285	WP_012105238.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
YPSIP31758_RS12440	2541239..2542255	-	1017	WP_012105239.1	terminase small subunit	-
YPSIP31758_RS12445	2542259..2542519	-	261	WP_012105240.1	hypothetical protein	-
YPSIP31758_RS12450	2542522..2543121	-	600	WP_197276492.1	protein Mom	-
YPSIP31758_RS12455	2543133..2543642	-	510	WP_012105242.1	ParB/Srx family N-terminal domain-containing protein	-
YPSIP31758_RS12460	2544119..2544319	+	201	WP_197276493.1	DUF2158 domain-containing protein	-
YPSIP31758_RS12465	2544367..2544603	+	237	WP_041175868.1	hypothetical protein	-
YPSIP31758_RS12470	2544820..2545089	-	270	WP_041175773.1	hypothetical protein	-
YPSIP31758_RS12475	2545388..2545651	-	264	Protein_2156	lysozyme	-
YPSIP31758_RS12480	2545651..2545866	-	216	WP_041175774.1	peptidoglycan-binding protein LysM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2500421..2558099	57678

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (2-76)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11186.99 Da
• Isoelectric Point: 10.3007

>T22333 WP_012105238.1 NC_009708:2540944-2541228 [Yersinia pseudotuberculosis IP 31758]
MTYNLDFDRRALKEWHKLGDTVRQQFKKKLLEVIKNPRVEANKLRDLPDCYKIKLRSAGYRLIYQVQDEKITVFVVAVGK
RDREEAYSEAGKRV

Nucleotide

• Length: 285 bp

>T22333 NC_009708:2540944-2541228 [Yersinia pseudotuberculosis IP 31758]
ATGACTTATAATCTTGATTTTGATCGCCGGGCGCTGAAGGAATGGCATAAGCTCGGCGATACCGTACGTCAGCAATTTAA
GAAAAAGCTGCTCGAAGTGATTAAAAATCCACGCGTTGAAGCCAATAAACTGCGCGACTTGCCTGATTGCTACAAAATAA
AACTACGCAGCGCCGGATACCGCCTGATTTATCAGGTGCAAGACGAAAAAATCACGGTTTTTGTGGTTGCCGTGGGTAAA
CGGGATCGTGAAGAAGCCTACAGTGAAGCTGGCAAGCGCGTCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8836.12 Da
• Isoelectric Point: 4.5105

>AT22333 WP_012105237.1 NC_009708:2540715-2540954 [Yersinia pseudotuberculosis IP 31758]
MGNINIRIDDDLKDRSYAVLEKLGVTPSDLLRQTLEYVAQSGKLPFKSVLLTDEDQALVAVVRERLANPQPVRVSLDDL

Nucleotide

• Length: 240 bp

>AT22333 NC_009708:2540715-2540954 [Yersinia pseudotuberculosis IP 31758]
ATGGGTAATATTAATATTCGCATTGATGATGACTTAAAAGATCGTTCTTATGCGGTACTGGAAAAACTGGGCGTCACCCC
CTCTGATTTACTGCGCCAGACGCTGGAATATGTGGCACAAAGTGGCAAACTGCCCTTTAAATCCGTGTTGCTGACTGATG
AAGATCAAGCATTGGTCGCCGTAGTCAGAGAACGTTTAGCCAATCCACAACCGGTCAGGGTGTCACTGGATGACTTATAA

Structures

Toxin

• AlphaFold DB: A0A209AEM7