Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2069189..2070155 Replicon chromosome
Accession NC_009708
Organism Yersinia pseudotuberculosis IP 31758

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag YPSIP31758_RS10300 Protein ID WP_002210981.1
Coordinates 2069189..2069647 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag YPSIP31758_RS10305 Protein ID WP_002210982.1
Coordinates 2069709..2070155 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPSIP31758_RS10270 2065003..2065668 + 666 WP_002210975.1 phage shock protein PspA -
YPSIP31758_RS10275 2065830..2066057 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
YPSIP31758_RS10280 2066057..2066416 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
YPSIP31758_RS10285 2066501..2066743 + 243 WP_002216375.1 phage shock protein PspD -
YPSIP31758_RS10290 2066724..2068121 + 1398 WP_012105043.1 YcjX family protein -
YPSIP31758_RS10295 2068118..2069179 + 1062 WP_012105044.1 YcjF family protein -
YPSIP31758_RS10300 2069189..2069647 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
YPSIP31758_RS10305 2069709..2070155 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
YPSIP31758_RS10310 2070492..2072069 + 1578 WP_011192519.1 transcriptional regulator TyrR -
YPSIP31758_RS10315 2072230..2072733 - 504 WP_002210984.1 thiol peroxidase -
YPSIP31758_RS10320 2072896..2073870 + 975 WP_012105045.1 L-Ala-D/L-Glu epimerase -
YPSIP31758_RS10325 2073912..2074619 - 708 WP_002220315.1 murein tripeptide amidase MpaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T22332 WP_002210981.1 NC_009708:c2069647-2069189 [Yersinia pseudotuberculosis IP 31758]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T22332 NC_009708:c2069647-2069189 [Yersinia pseudotuberculosis IP 31758]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT22332 WP_002210982.1 NC_009708:c2070155-2069709 [Yersinia pseudotuberculosis IP 31758]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT22332 NC_009708:c2070155-2069709 [Yersinia pseudotuberculosis IP 31758]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGATTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References