Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1056562..1057234 Replicon chromosome
Accession NC_009708
Organism Yersinia pseudotuberculosis IP 31758

Toxin (Protein)


Gene name cptA Uniprot ID A0A0U1R236
Locus tag YPSIP31758_RS05700 Protein ID WP_012104676.1
Coordinates 1056809..1057234 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag YPSIP31758_RS05695 Protein ID WP_002209939.1
Coordinates 1056562..1056828 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPSIP31758_RS05675 1052369..1053472 + 1104 WP_012104675.1 hypothetical protein -
YPSIP31758_RS05680 1053674..1054375 + 702 WP_002209942.1 hemolysin III family protein -
YPSIP31758_RS05685 1054684..1055181 + 498 WP_002209941.1 DUF2165 family protein -
YPSIP31758_RS05690 1055254..1056246 - 993 WP_011192958.1 tRNA-modifying protein YgfZ -
YPSIP31758_RS05695 1056562..1056828 + 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
YPSIP31758_RS05700 1056809..1057234 + 426 WP_012104676.1 protein YgfX Toxin
YPSIP31758_RS05705 1057234..1057932 + 699 WP_012104677.1 two-component system response regulator CreB -
YPSIP31758_RS05710 1057957..1059390 + 1434 WP_012104678.1 two-component system sensor histidine kinase CreC -
YPSIP31758_RS05715 1059475..1060932 + 1458 WP_012104679.1 cell envelope integrity protein CreD -
YPSIP31758_RS05720 1061017..1061535 - 519 WP_011192956.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16467.40 Da        Isoelectric Point: 10.1176

>T22330 WP_012104676.1 NC_009708:1056809-1057234 [Yersinia pseudotuberculosis IP 31758]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVLWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T22330 NC_009708:1056809-1057234 [Yersinia pseudotuberculosis IP 31758]
GTGGCCCAGTGGCGATGTAACCTGCGGGTATCCTGGCATACTCAACTCTTTTCTTTATTGGCGCACGGCATATTGGTCAT
TTTAACCTTGGTCGCGCCCTGGCCCTTGGGTTATACCGCCCTATGGCTGGTATTGCTGACGTTAGTGGTGTTTGAGTGTA
TCCGCAGCCAGAAAAGGATTAAATCCTGTCAGGGGGAAATCAGGCTAAAACCTGGCAACCTGGTGCTATGGAAAAGGCAT
GAATGGACCGTGGTCAAGCCGCCGTGGATCACCCGCTATGGGGTATTATTACATTTACAACAAACAGGCGGCCATGCGAC
CCGAAAGCGTCTATGGCTGTCCGCTGACAGCATGTCTGAAGATGAGTGGCGGCAGCTATGCCTGTTGCTGCGGCATTCAT
TTGAATCTGACGATGGAACGATGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT22330 WP_002209939.1 NC_009708:1056562-1056828 [Yersinia pseudotuberculosis IP 31758]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT22330 NC_009708:1056562-1056828 [Yersinia pseudotuberculosis IP 31758]
ATGGAAATTGATAATAAAGCCCGCATTCACTGGGCATGCCGCCGTGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTTGAATATGAATATGATAGCTTGAGCGATAACGAGAAACAGGCATTTATCCGCTTGCTTGAGTGTGATGATCCAGATT
TATTCAACTGGCTGATGAACCACGGGGAGCCGCAGGATAGCGAGCTATATCAGATGGTCAAACTGATTCAATCACGAAAT
AAAGCCCGTGGCCCAGTGGCGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1R236

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References