Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeV-yfjZ/CbtA-CbeA |
| Location | 911931..912619 | Replicon | chromosome |
| Accession | NC_009708 | ||
| Organism | Yersinia pseudotuberculosis IP 31758 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0U1QY13 |
| Locus tag | YPSIP31758_RS05120 | Protein ID | WP_012104596.1 |
| Coordinates | 912263..912619 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A0U1QVL0 |
| Locus tag | YPSIP31758_RS05115 | Protein ID | WP_012104595.1 |
| Coordinates | 911931..912251 (-) | Length | 107 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| YPSIP31758_RS23960 | 907446..908143 | + | 698 | WP_115027165.1 | IS1-like element ISYps7 family transposase | - |
| YPSIP31758_RS05090 | 908752..909381 | + | 630 | WP_041175740.1 | DUF2345 domain-containing protein | - |
| YPSIP31758_RS05095 | 909405..909713 | + | 309 | Protein_724 | site-specific integrase | - |
| YPSIP31758_RS05100 | 910172..910459 | - | 288 | WP_012104592.1 | helix-turn-helix transcriptional regulator | - |
| YPSIP31758_RS05105 | 910446..910769 | - | 324 | WP_012104593.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| YPSIP31758_RS05110 | 910969..911835 | - | 867 | WP_012104594.1 | DUF4942 domain-containing protein | - |
| YPSIP31758_RS05115 | 911931..912251 | - | 321 | WP_012104595.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| YPSIP31758_RS05120 | 912263..912619 | - | 357 | WP_012104596.1 | TA system toxin CbtA family protein | Toxin |
| YPSIP31758_RS05125 | 912675..913007 | - | 333 | WP_012104597.1 | hypothetical protein | - |
| YPSIP31758_RS05130 | 913001..913474 | - | 474 | WP_041175841.1 | DNA repair protein RadC | - |
| YPSIP31758_RS05135 | 913506..913937 | - | 432 | WP_012104600.1 | antirestriction protein | - |
| YPSIP31758_RS05140 | 914065..914325 | - | 261 | WP_012104601.1 | hypothetical protein | - |
| YPSIP31758_RS05145 | 914325..915146 | - | 822 | WP_012104602.1 | DUF945 domain-containing protein | - |
| YPSIP31758_RS05150 | 915243..915710 | - | 468 | WP_012104604.1 | hypothetical protein | - |
| YPSIP31758_RS05155 | 915814..916350 | - | 537 | WP_012104605.1 | DUF4339 domain-containing protein | - |
| YPSIP31758_RS05160 | 916473..917093 | - | 621 | WP_012104606.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | vipA/tssB / vipB/tssC / vasE/tssK / hcp/tssD / clpV/tssH | 885448..917800 | 32352 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12999.94 Da Isoelectric Point: 6.8771
>T22329 WP_012104596.1 NC_009708:c912619-912263 [Yersinia pseudotuberculosis IP 31758]
MKPRATAQGALPVPVIYQQLLAFLLEHHYGLSLNDTPYHDEQVIAQQIEQGISVGDTINALVDKYALVRIGRNGFSALVQ
DPMLSKGDIARARQAAGLWRAHFPPTLLYPTESLNPIP
MKPRATAQGALPVPVIYQQLLAFLLEHHYGLSLNDTPYHDEQVIAQQIEQGISVGDTINALVDKYALVRIGRNGFSALVQ
DPMLSKGDIARARQAAGLWRAHFPPTLLYPTESLNPIP
Download Length: 357 bp
>T22329 NC_009708:c912619-912263 [Yersinia pseudotuberculosis IP 31758]
ATGAAACCACGCGCCACAGCGCAGGGTGCATTGCCCGTGCCTGTTATTTATCAGCAACTGCTCGCTTTTCTGCTGGAGCA
CCACTATGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGTGATTGCACAGCAGATAGAACAAGGGATTTCAG
TGGGCGATACCATTAATGCATTGGTTGATAAATATGCATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGTACAA
GACCCGATGCTGAGTAAGGGTGATATCGCCCGTGCTCGCCAGGCCGCAGGTCTGTGGCGTGCGCATTTTCCGCCAACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCCATAG
ATGAAACCACGCGCCACAGCGCAGGGTGCATTGCCCGTGCCTGTTATTTATCAGCAACTGCTCGCTTTTCTGCTGGAGCA
CCACTATGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGTGATTGCACAGCAGATAGAACAAGGGATTTCAG
TGGGCGATACCATTAATGCATTGGTTGATAAATATGCATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGTACAA
GACCCGATGCTGAGTAAGGGTGATATCGCCCGTGCTCGCCAGGCCGCAGGTCTGTGGCGTGCGCATTTTCCGCCAACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCCATAG
Antitoxin
Download Length: 107 a.a. Molecular weight: 11579.17 Da Isoelectric Point: 7.4210
>AT22329 WP_012104595.1 NC_009708:c912251-911931 [Yersinia pseudotuberculosis IP 31758]
MDNHMTTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSPQAAQALDVAFPALITKLESQMLSGALDPRRQQG
ITVRHGGFVCDADTLGSHGYVYIAVY
MDNHMTTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSPQAAQALDVAFPALITKLESQMLSGALDPRRQQG
ITVRHGGFVCDADTLGSHGYVYIAVY
Download Length: 321 bp
>AT22329 NC_009708:c912251-911931 [Yersinia pseudotuberculosis IP 31758]
ATGGATAACCACATGACTACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCACGTTTGGGAGCCAGACTGGTGCA
GGAAGGAACACACCTGCACTTTCTGAGTGACAGAGCCAATATTGTCGGCACCTTTTCCCCTCAAGCCGCTCAGGCTCTTG
ATGTGGCATTCCCAGCGCTGATAACCAAACTGGAGTCGCAGATGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCACGGGGGATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGTTATGTCTACATCGCGGTGTATTA
G
ATGGATAACCACATGACTACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCACGTTTGGGAGCCAGACTGGTGCA
GGAAGGAACACACCTGCACTTTCTGAGTGACAGAGCCAATATTGTCGGCACCTTTTCCCCTCAAGCCGCTCAGGCTCTTG
ATGTGGCATTCCCAGCGCTGATAACCAAACTGGAGTCGCAGATGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCACGGGGGATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGTTATGTCTACATCGCGGTGTATTA
G
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U1QY13 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U1QVL0 |