Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4191916..4192535 Replicon chromosome
Accession NZ_CP086423
Organism Klebsiella pneumoniae strain AE-2247421-T20-MAC

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LNN44_RS20690 Protein ID WP_002892050.1
Coordinates 4192317..4192535 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LNN44_RS20685 Protein ID WP_002892066.1
Coordinates 4191916..4192290 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN44_RS20675 (4187068) 4187068..4188261 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LNN44_RS20680 (4188284) 4188284..4191430 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LNN44_RS20685 (4191916) 4191916..4192290 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LNN44_RS20690 (4192317) 4192317..4192535 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LNN44_RS20695 (4192694) 4192694..4193260 + 567 WP_002892030.1 maltose O-acetyltransferase -
LNN44_RS20700 (4193232) 4193232..4193372 - 141 WP_004147370.1 hypothetical protein -
LNN44_RS20705 (4193393) 4193393..4193863 + 471 WP_002892026.1 YlaC family protein -
LNN44_RS20710 (4193838) 4193838..4195289 - 1452 WP_032419337.1 PLP-dependent aminotransferase family protein -
LNN44_RS20715 (4195390) 4195390..4196088 + 699 WP_002892021.1 GNAT family protein -
LNN44_RS20720 (4196085) 4196085..4196225 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LNN44_RS20725 (4196225) 4196225..4196488 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T223286 WP_002892050.1 NZ_CP086423:4192317-4192535 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T223286 NZ_CP118630:622207-622539 [Pantoea dispersa]
ATGGTGTCACGTTTTGTTCCCGATGCAGGCGATCTCATCTGGCTGGATTTTGATCCCACCCTTGGCCATGAACAGGGCGG
CCATCGTCCTGCGGTTGTGCTGAGTCCCTTTGCCTATAACAACAAGGTCGGCATGTTGTTGTGCGTCCCGTGTACCACCC
AGGTCAAAGGCTATCCTTTCGAAGTTTCCCTTACCGGTAGCCGTGATAGTGTGGCGCTGGCCGATCAGGTCACCTCCATC
GACTGGCGCGCCAGAAAAGTGGTGAAAAAAAGCCATGTGACCGCCGAGGAACTGAGTGAGATTCGCGCTAAAGCTAAAGC
GCTGATTGGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT223286 WP_002892066.1 NZ_CP086423:4191916-4192290 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT223286 NZ_CP118630:621962-622207 [Pantoea dispersa]
ATGACGACCGTCACCTTAAAGAAATGGGGCAACAGTCCCTCGATTCGCATCCCATCCAGCGTGATGCAATCCGCGTCGCT
CAGCGTGGACGATAAACTGGAACTCAGCGTTGAAGATGGCAAGCTGATCCTTGTGCCGCTCAGGGAAAAGGTGTATTCAC
TGGACGCTCTGCTGGACGAGATCACCGACGATAACGTCCATGATAAAATTGATTTTGGACCTTCAGTGGGCAAGGAAAGA
ATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References