Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 81709..82290 Replicon plasmid plasmid_153kb
Accession NC_009705
Organism Yersinia pseudotuberculosis IP 31758

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag YPSIP31758_RS00760 Protein ID WP_041175657.1
Coordinates 81709..82041 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A0U1QTL2
Locus tag YPSIP31758_RS00765 Protein ID WP_011988565.1
Coordinates 82045..82290 (-) Length 82 a.a.

Genomic Context

YPSIP31758_RS00750YPSIP31758_RS00785YPSIP31758_RS24200YPSIP31758_RS00740YPSIP31758_RS00745YPSIP31758_RS00755YPSIP31758_RS00760YPSIP31758_RS00765YPSIP31758_RS00770YPSIP31758_RS00775
Location: 80522..80860 (339 bp)
Type: Others
Protein ID: WP_041175655.1
Location: 85320..85781 (462 bp)
Type: Others
Protein ID: WP_041175659.1
Location: 85756..85902 (147 bp)
Type: Others
Protein ID: WP_165285902.1
Location: 78329..79402 (1074 bp)
Type: Others
Protein ID: WP_011988612.1
Location: 79827..80105 (279 bp)
Type: Others
Protein ID: WP_041175654.1
Location: 81046..81588 (543 bp)
Type: Others
Protein ID: WP_041175656.1
Location: 81709..82041 (333 bp)
Type: Toxin
Protein ID: WP_041175657.1
Location: 82045..82290 (246 bp)
Type: Antitoxin
Protein ID: WP_011988565.1
Location: 82551..83390 (840 bp)
Type: Others
Protein ID: WP_011988487.1
Location: 83794..84912 (1119 bp)
Type: Others
Protein ID: WP_011988604.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
YPSIP31758_RS0074078329..79402-1074WP_011988612.1DUF4935 domain-containing protein-
YPSIP31758_RS0074579827..80105-279WP_041175654.1hypothetical protein-
YPSIP31758_RS0075080522..80860+339WP_041175655.1hypothetical protein-
YPSIP31758_RS0075581046..81588-543WP_041175656.1hypothetical protein-
YPSIP31758_RS0076081709..82041-333WP_041175657.1endoribonuclease MazFToxin
YPSIP31758_RS0076582045..82290-246WP_011988565.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
YPSIP31758_RS0077082551..83390-840WP_011988487.1hypothetical protein-
YPSIP31758_RS0077583794..84912-1119WP_011988604.1hypothetical protein-
YPSIP31758_RS0078585320..85781+462WP_041175659.1hypothetical protein-
YPSIP31758_RS2420085756..85902+147WP_165285902.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..153140153140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-104)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12120.19 Da        Isoelectric Point: 9.8470

>T22328 WP_041175657.1 NC_009705:c82041-81709 [Yersinia pseudotuberculosis IP 31758]
MIKNYVPEAGDIVWLDFDPQAGHEQAGHRPALVLSPAIYNEKVGLMLCCPMTTQIKGYPFEVIIAGTKPSAVLSDQIKSL
DWRKRKATRKGRVSALELSEVRAKSKALIG

Download         Length: 333 bp

>T22328 NC_009705:c82041-81709 [Yersinia pseudotuberculosis IP 31758]
ATGATTAAAAATTACGTTCCTGAAGCTGGCGACATAGTGTGGCTTGATTTTGATCCACAGGCTGGCCATGAGCAAGCGGG
GCATAGACCTGCTCTTGTACTAAGCCCAGCGATATATAATGAAAAAGTTGGGTTAATGTTGTGTTGTCCGATGACGACGC
AGATTAAGGGCTATCCATTTGAAGTAATTATCGCAGGAACAAAGCCAAGTGCAGTTTTATCAGATCAAATTAAAAGCCTA
GACTGGCGTAAACGTAAAGCTACACGAAAAGGGCGTGTATCCGCGCTTGAATTATCTGAAGTAAGAGCTAAATCGAAGGC
TTTAATTGGCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8847.34 Da        Isoelectric Point: 5.8065

>AT22328 WP_011988565.1 NC_009705:c82290-82045 [Yersinia pseudotuberculosis IP 31758]
MAQVIVKKWGNSPSVRLPVAVMEAASLKIDDTVDIVVEDGRIVIVPVRAKEISLQSLLGRLTDDNIHREVDFGKPVGKEA
L

Download         Length: 246 bp

>AT22328 NC_009705:c82290-82045 [Yersinia pseudotuberculosis IP 31758]
ATGGCACAAGTTATAGTAAAAAAATGGGGCAATAGTCCTTCTGTAAGACTGCCTGTTGCAGTTATGGAAGCCGCCAGTTT
GAAGATAGATGATACTGTAGATATCGTGGTTGAAGATGGGCGTATTGTTATTGTGCCAGTACGGGCTAAAGAAATATCGC
TGCAATCGCTATTAGGTAGACTAACTGACGATAATATCCACCGCGAAGTAGATTTCGGGAAGCCTGTAGGGAAAGAGGCA
CTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0U1QTL2

References