22327

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParE-CopA/ParE-RHH
Location 1836..2416 Replicon plasmid plasmid_59kb
Accession NC_009704
Organism Yersinia pseudotuberculosis IP 31758

Toxin (Protein)


Gene name parE Uniprot ID A0A0U1QT96
Locus tag YPSIP31758_RS00010 Protein ID WP_011988449.1
Coordinates 1836..2138 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name copA Uniprot ID A0A0U1QTB9
Locus tag YPSIP31758_RS00015 Protein ID WP_011988472.1
Coordinates 2126..2416 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPSIP31758_RS00005 519..1376 - 858 WP_147654424.1 Replication protein -
YPSIP31758_RS00010 1836..2138 - 303 WP_011988449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
YPSIP31758_RS00015 2126..2416 - 291 WP_011988472.1 CopG family transcriptional regulator Antitoxin
YPSIP31758_RS24175 3122..3289 - 168 WP_166485334.1 hypothetical protein -
YPSIP31758_RS00020 3354..3548 - 195 WP_041175615.1 hypothetical protein -
YPSIP31758_RS22360 3928..4839 - 912 WP_011988417.1 zeta toxin family protein -
YPSIP31758_RS00030 4836..5057 - 222 WP_041175616.1 hypothetical protein -
YPSIP31758_RS00035 5634..6002 + 369 WP_011988477.1 transcriptional regulator -
YPSIP31758_RS00040 6161..7120 + 960 WP_041175630.1 P-type conjugative transfer ATPase TrbB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..58679 58679


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11494.30 Da        Isoelectric Point: 5.1546

>T22327 WP_011988449.1 NC_009704:c2138-1836 [Yersinia pseudotuberculosis IP 31758]
VPRLIWTQEAIQDVDRLYKFLAEKNVEAARKAAKVILDETTKIEAFPEIGRPAEFINVYCRELLVPFGVSGYVVLYRYDG
QLTTILAVKHQFEAGYLPEF

Download         Length: 303 bp

>T22327 NC_009704:c2138-1836 [Yersinia pseudotuberculosis IP 31758]
GTGCCACGTCTGATTTGGACTCAGGAGGCGATACAAGATGTAGATCGCCTCTATAAATTTTTAGCAGAGAAGAATGTAGA
AGCTGCAAGAAAAGCAGCAAAAGTAATTTTAGATGAAACTACTAAAATTGAGGCATTTCCTGAAATTGGACGACCCGCTG
AGTTTATAAATGTGTATTGCAGAGAGTTGTTAGTGCCGTTCGGTGTAAGTGGATATGTAGTGTTATACCGATATGATGGC
CAACTAACCACTATCTTAGCTGTAAAACATCAGTTTGAAGCGGGGTATCTGCCAGAGTTTTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11173.62 Da        Isoelectric Point: 6.7575

>AT22327 WP_011988472.1 NC_009704:c2416-2126 [Yersinia pseudotuberculosis IP 31758]
MKTSSNTPVSVKIEPTIKARMERLGESRERTMHWLVTDAIKKYVEHEEKREELKEAAHKAWLSFQETGLHVSSEEANEWL
TSLSEGHYKEPPKCHV

Download         Length: 291 bp

>AT22327 NC_009704:c2416-2126 [Yersinia pseudotuberculosis IP 31758]
ATGAAGACCTCTTCCAATACACCTGTATCAGTCAAGATTGAGCCAACTATTAAGGCTCGTATGGAACGTTTGGGTGAAAG
CCGTGAACGTACTATGCACTGGCTAGTTACAGATGCTATCAAGAAGTATGTTGAACATGAAGAGAAAAGAGAAGAGTTAA
AAGAGGCCGCTCATAAAGCTTGGCTATCCTTCCAAGAAACTGGCTTGCATGTTTCATCTGAAGAGGCCAATGAATGGCTC
ACCAGTTTGTCGGAGGGGCATTATAAGGAACCTCCTAAGTGCCACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1QT96

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1QTB9

References