Detailed information of TA system TA022326

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4835465..4836569
• Replicon: chromosome
• Accession: NC_009675
• Organism: Anaeromyxobacter sp. Fw109-5

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ANAE109_RS21210
• Protein ID: WP_049768663.1
• Coordinates: 4835889..4836569 (+)
• Length: 227 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: ANAE109_RS21205
• Protein ID: WP_041448595.1
• Coordinates: 4835465..4835839 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ANAE109_RS21195	4831438..4834104	-	2667	WP_012098945.1	pyruvate dehydrogenase (acetyl-transferring), homodimeric type	-
ANAE109_RS21200	4834346..4835332	+	987	WP_012098946.1	zinc-dependent alcohol dehydrogenase family protein	-
ANAE109_RS21205	4835465..4835839	+	375	WP_041448595.1	DUF2384 domain-containing protein	Antitoxin
ANAE109_RS21210	4835889..4836569	+	681	WP_049768663.1	RES family NAD+ phosphorylase	Toxin
ANAE109_RS21215	4836637..4837479	+	843	WP_012098949.1	EcsC family protein	-
ANAE109_RS21220	4837814..4838215	+	402	WP_012098950.1	four helix bundle protein	-
ANAE109_RS21225	4838485..4838895	-	411	WP_012098951.1	four helix bundle protein	-
ANAE109_RS21230	4839227..4839964	-	738	WP_041449526.1	metallophosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (36-183)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (75-122)

Sequences

Toxin

Protein

• Length: 227 a.a.
• Molecular weight: 24781.11 Da
• Isoelectric Point: 6.4931

>T22326 WP_049768663.1 NC_009675:4835889-4836569 [Anaeromyxobacter sp. Fw109-5]
MISTRPLVDTDAEHDLLERMIDAQKPPLPPDPAFAGLHYLLYSPFRYPPLRYGSRFGGRHEPSLWYGSEELPTALAETAY
YRIVFFEGTEAKLAPHAMPFSAFQVKVATRAGVDLSSPAFKGAARRICSPSDYTASQRLGAEMRADGIEVVRYPSARDPR
RGPNVGLFSPAAFAAPAPLATPETWYCTVTGAHDVEFRHERALGIDTELFPRSTFLVDGALPAPAA

Nucleotide

• Length: 681 bp

>T22326 NC_009675:4835889-4836569 [Anaeromyxobacter sp. Fw109-5]
ATGATCTCCACGCGGCCCCTCGTGGACACCGACGCCGAGCACGACCTGCTCGAGCGCATGATCGACGCGCAGAAGCCGCC
GCTGCCGCCGGACCCCGCGTTCGCGGGGCTGCACTACCTCCTCTACTCGCCGTTCCGGTACCCGCCGCTCCGCTACGGCT
CGCGCTTCGGCGGACGCCACGAGCCGAGCCTCTGGTACGGGTCCGAGGAGCTGCCCACCGCGCTCGCCGAGACGGCGTAT
TACCGGATCGTGTTCTTCGAGGGCACGGAGGCGAAGCTCGCGCCCCACGCCATGCCGTTCTCGGCGTTCCAGGTGAAGGT
CGCCACCCGCGCGGGCGTGGACCTCTCGTCGCCCGCCTTCAAGGGCGCGGCCCGCCGGATCTGCTCGCCCTCCGACTACA
CCGCCAGCCAGCGGCTCGGCGCCGAGATGCGGGCGGACGGGATCGAGGTCGTCCGCTACCCCTCGGCGCGCGACCCGCGC
CGGGGCCCGAACGTGGGGCTCTTCTCGCCGGCCGCGTTCGCGGCGCCGGCTCCCCTCGCGACGCCCGAGACCTGGTACTG
CACGGTCACCGGGGCGCACGACGTCGAGTTTCGCCACGAGCGGGCGCTGGGCATCGACACCGAGCTCTTCCCGCGCAGCA
CGTTCCTCGTCGACGGCGCGCTGCCGGCGCCCGCTGCCTGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 12990.03 Da
• Isoelectric Point: 10.6629

>AT22326 WP_041448595.1 NC_009675:4835465-4835839 [Anaeromyxobacter sp. Fw109-5]
MRASAHARAPEPGAVLTKATLRAAELLGLTDAQLARIIGVSGASVSRLRAASRSIDPAAKEGELALTFLRMYRSLNALLG
DAASCRAWFHAENAHLGGAPALLVRGVEGLVNVTQYLDAMRGKV

Nucleotide

• Length: 375 bp

>AT22326 NC_009675:4835465-4835839 [Anaeromyxobacter sp. Fw109-5]
ATGCGCGCATCCGCCCACGCGAGGGCGCCCGAGCCGGGCGCGGTGCTGACCAAGGCGACGCTCCGCGCGGCCGAGCTGCT
CGGGCTCACCGACGCGCAGCTCGCGAGGATCATCGGCGTCAGCGGCGCCTCGGTCTCGCGGCTCCGCGCCGCCTCGCGCT
CGATCGACCCCGCGGCCAAGGAGGGCGAGCTCGCGCTCACTTTCCTGCGCATGTACCGCAGCCTCAATGCTTTACTGGGA
GACGCAGCGAGCTGCCGCGCGTGGTTCCACGCCGAGAACGCTCACCTCGGCGGCGCTCCCGCGCTCCTGGTGCGGGGCGT
CGAAGGGCTGGTGAATGTCACGCAGTATCTGGACGCGATGCGGGGGAAGGTCTAG