Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 799217..799874 Replicon chromosome
Accession NZ_CP086416
Organism Klebsiella pneumoniae strain AE-2247421-T20-ESBL

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LNN42_RS03990 Protein ID WP_002916310.1
Coordinates 799464..799874 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LNN42_RS03985 Protein ID WP_002916312.1
Coordinates 799217..799483 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LNN42_RS03960 (794373) 794373..795806 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
LNN42_RS03965 (795925) 795925..796653 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LNN42_RS03970 (796703) 796703..797014 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LNN42_RS03975 (797178) 797178..797837 + 660 WP_002916317.1 hemolysin III family protein -
LNN42_RS03980 (797988) 797988..798971 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LNN42_RS03985 (799217) 799217..799483 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LNN42_RS03990 (799464) 799464..799874 + 411 WP_002916310.1 protein YgfX Toxin
LNN42_RS03995 (799881) 799881..800402 - 522 WP_004144730.1 flavodoxin FldB -
LNN42_RS04000 (800503) 800503..801399 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LNN42_RS04005 (801422) 801422..802135 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LNN42_RS04010 (802141) 802141..803874 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T223254 WP_002916310.1 NZ_CP086416:799464-799874 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T223254 NZ_CP118607:c1589571-1589269 [Pseudomonas sp. PSKL.D1]
ATGAAAAAAATCGAATCCAGCAGCTTCAGGAAGTGGGTGATCGGACTCAAAGATGCCAAGGCAAGAGTCAGGATCATCTC
GCGCATCAACCGACTCATGGAAGGCATATCCGGCGATGTCTCGCCGGTTGGGCATGGCGTCAGTGAACTCAGAATCCACC
TCGGGCCTGGCTACCGTGTGTACTTTCACCAATCGGGCGATACCTTGGTGATATTGCTTTGCGGTGGTGACAAAGATAGC
CAGCAACGAGACATCAAGGCTGCCCACCAGATTCTGCGCGCGTGGAGGATGCAAAATGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT223254 WP_002916312.1 NZ_CP086416:799217-799483 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT223254 NZ_CP118607:c1589276-1588983 [Pseudomonas sp. PSKL.D1]
ATGACTGACACCTTTTTTGAGTTTGACCCGGCCGACTACCTCACTACACCCGAGGCCATCGCACTATTCATGACCGACGC
CCTGGAAACAGGAGACGCCAGCTACGTGGCCAAAGCTGTCGGTGTGGTGGCACGGGCCAAAGGTATGACGGAGTTGGCCA
AAGAAACCGGCTTGTCTCGTGAACAGCTTTATCGCTCGTTCAGCGAGCACGGCAACCCAACGCTCAAATCATTTTTGGCG
GTAATGAAAGCACTGGGTATAGACATGACCGCAACGCCTCATCTGGCACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References