Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4069139..4069920 Replicon chromosome
Accession NZ_CP086408
Organism Enterobacter cloacae strain POL9

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5E1AVC8
Locus tag LMJ45_RS19490 Protein ID WP_029882967.1
Coordinates 4069139..4069630 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A5E1AUV7
Locus tag LMJ45_RS19495 Protein ID WP_029882966.1
Coordinates 4069627..4069920 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMJ45_RS19440 (LMJ45_19440) 4064246..4064713 + 468 WP_001547765.1 protein YkfB -
LMJ45_RS19445 (LMJ45_19445) 4064790..4065029 + 240 WP_128312140.1 DUF905 domain-containing protein -
LMJ45_RS19450 (LMJ45_19450) 4065127..4065585 + 459 WP_000211838.1 antirestriction protein -
LMJ45_RS19455 (LMJ45_19455) 4065601..4066077 + 477 WP_000811693.1 RadC family protein -
LMJ45_RS19460 (LMJ45_19460) 4066086..4066307 + 222 WP_000691994.1 DUF987 domain-containing protein -
LMJ45_RS19465 (LMJ45_19465) 4066326..4066652 + 327 WP_001548930.1 type IV toxin-antitoxin system antitoxin YafW -
LMJ45_RS19470 (LMJ45_19470) 4066742..4067119 + 378 WP_000854726.1 TA system toxin CbtA family protein -
LMJ45_RS19475 (LMJ45_19475) 4067116..4067604 + 489 WP_128312139.1 DUF5983 family protein -
LMJ45_RS19480 (LMJ45_19480) 4067616..4067813 + 198 WP_000839269.1 DUF957 domain-containing protein -
LMJ45_RS19485 (LMJ45_19485) 4067898..4068740 + 843 WP_128312147.1 DUF4942 domain-containing protein -
LMJ45_RS19490 (LMJ45_19490) 4069139..4069630 - 492 WP_029882967.1 GNAT family N-acetyltransferase Toxin
LMJ45_RS19495 (LMJ45_19495) 4069627..4069920 - 294 WP_029882966.1 DUF1778 domain-containing protein Antitoxin
LMJ45_RS19500 (LMJ45_19500) 4070169..4071956 - 1788 WP_062729673.1 hybrid sensor histidine kinase/response regulator -
LMJ45_RS19505 (LMJ45_19505) 4071953..4072585 - 633 WP_128312137.1 response regulator transcription factor -
LMJ45_RS19510 (LMJ45_19510) 4072761..4073075 + 315 WP_013098694.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17629.53 Da        Isoelectric Point: 7.2653

>T223212 WP_029882967.1 NZ_CP086408:c4069630-4069139 [Enterobacter cloacae]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVSGASRTFVCCGNDSNVLAYYSLASSAVMTNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLM
ASI

Download         Length: 492 bp

>T223212 NZ_CP118584:c1608989-1608657 [Vibrio harveyi]
ATGAAAAGTGTATTTGTCGAATCAACCATATTTGAAAAGTACCGTAATGAATATCTCAGCGATGATGAGTTTAGGCTTTT
TCAAGCTGAGTTAATGTCTAACCCGAAGCAGGGTGACGTGATTCAAGGTACAGGTGGTTTGCGAAAGATTCGAGTTGCAA
GTAAAGGTAAGGGCAAGCGTGGTGGTTCTCGCGTTATCTATTACTTCCTCGATGAAAAGCGTCGTTTCTACTTGCTGACG
ATTTACGGCAAGAATGAAATGTCCGACTTAACCGCAGACCAAAAGAAACAACTAAAGGCTTTTATGGAGGCGTGGCGTAA
TGAGCAGTCGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11003.66 Da        Isoelectric Point: 9.9156

>AT223212 WP_029882966.1 NZ_CP086408:c4069920-4069627 [Enterobacter cloacae]
MPAANTMAMKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQAPAPN
ATLRKTMQTPAPWEREK

Download         Length: 294 bp

>AT223212 NZ_CP118584:c1608670-1608356 [Vibrio harveyi]
ATGAGCAGTCGTGATTTATTTGCAGAGTTAAGTTCAGCACTTGTTGAGGCTAAAGAGCATTCAGAGGGCAAGCTTACCCT
TAAAACTCATCAAGTTAACGACATTAGTGAGTTAAATATCTCACCTGATGAAATCGTGAGTATTCGAGAGCAGTTTAATA
TGTCTCGTGGTGTGTTTGCTCGTTTGTTGCACACATCATCTCGTACGTTAGAAAACTGGGAGCAAGGGCGTAGCGCACCA
AATGGACAAGCCGTAACACTTCTAAAGTTGGTTCAGCGTCATCCAGAAACCCTGTCGCACATCGCTGAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AVC8

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AUV7

References