Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeV-yafW/CbtA-CbeA |
| Location | 4066326..4067119 | Replicon | chromosome |
| Accession | NZ_CP086408 | ||
| Organism | Enterobacter cloacae strain POL9 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1EZ92 |
| Locus tag | LMJ45_RS19470 | Protein ID | WP_000854726.1 |
| Coordinates | 4066742..4067119 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EBQ7 |
| Locus tag | LMJ45_RS19465 | Protein ID | WP_001548930.1 |
| Coordinates | 4066326..4066652 (+) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMJ45_RS19420 (LMJ45_19420) | 4061767..4062588 | + | 822 | WP_128312143.1 | DUF932 domain-containing protein | - |
| LMJ45_RS19425 (LMJ45_19425) | 4062806..4063507 | + | 702 | WP_001548933.1 | WYL domain-containing protein | - |
| LMJ45_RS19430 (LMJ45_19430) | 4063544..4063780 | + | 237 | WP_001115854.1 | protein YpjK | - |
| LMJ45_RS19435 (LMJ45_19435) | 4063780..4064217 | + | 438 | WP_116291333.1 | lipoprotein YafY | - |
| LMJ45_RS19440 (LMJ45_19440) | 4064246..4064713 | + | 468 | WP_001547765.1 | protein YkfB | - |
| LMJ45_RS19445 (LMJ45_19445) | 4064790..4065029 | + | 240 | WP_128312140.1 | DUF905 domain-containing protein | - |
| LMJ45_RS19450 (LMJ45_19450) | 4065127..4065585 | + | 459 | WP_000211838.1 | antirestriction protein | - |
| LMJ45_RS19455 (LMJ45_19455) | 4065601..4066077 | + | 477 | WP_000811693.1 | RadC family protein | - |
| LMJ45_RS19460 (LMJ45_19460) | 4066086..4066307 | + | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| LMJ45_RS19465 (LMJ45_19465) | 4066326..4066652 | + | 327 | WP_001548930.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| LMJ45_RS19470 (LMJ45_19470) | 4066742..4067119 | + | 378 | WP_000854726.1 | TA system toxin CbtA family protein | Toxin |
| LMJ45_RS19475 (LMJ45_19475) | 4067116..4067604 | + | 489 | WP_128312139.1 | DUF5983 family protein | - |
| LMJ45_RS19480 (LMJ45_19480) | 4067616..4067813 | + | 198 | WP_000839269.1 | DUF957 domain-containing protein | - |
| LMJ45_RS19485 (LMJ45_19485) | 4067898..4068740 | + | 843 | WP_128312147.1 | DUF4942 domain-containing protein | - |
| LMJ45_RS19490 (LMJ45_19490) | 4069139..4069630 | - | 492 | WP_029882967.1 | GNAT family N-acetyltransferase | - |
| LMJ45_RS19495 (LMJ45_19495) | 4069627..4069920 | - | 294 | WP_029882966.1 | DUF1778 domain-containing protein | - |
| LMJ45_RS19500 (LMJ45_19500) | 4070169..4071956 | - | 1788 | WP_062729673.1 | hybrid sensor histidine kinase/response regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14164.10 Da Isoelectric Point: 7.8045
>T223211 WP_000854726.1 NZ_CP086408:4066742-4067119 [Enterobacter cloacae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T223211 NZ_CP118584:1589117-1589395 [Vibrio harveyi]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGGGTACAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTCTCTTACTGGATTGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGGGTACAACGAGATGGCA
TCCGCGGACGATTACTCATCATTCCTGAGATTTCGATGATTGTCTCTTACTGGATTGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACGGATTGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 12301.97 Da Isoelectric Point: 7.0273
>AT223211 WP_001548930.1 NZ_CP086408:4066326-4066652 [Enterobacter cloacae]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK
Download Length: 327 bp
>AT223211 NZ_CP118584:1588836-1589120 [Vibrio harveyi]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGCAC
TCTGAGTGACGCATGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|