Detailed information of TA system TA022320

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 661077..661774
• Replicon: chromosome
• Accession: NC_009667
• Organism: Ochrobactrum anthropi ATCC 49188

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: OANT_RS03280
• Protein ID: WP_040130219.1
• Coordinates: 661349..661774 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A256H0E6
• Locus tag: OANT_RS03275
• Protein ID: WP_012090891.1
• Coordinates: 661077..661349 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OANT_RS03250	656767..657687	+	921	WP_012090886.1	glutathione ABC transporter permease GsiC	-
OANT_RS03255	657684..658568	+	885	WP_012090887.1	ABC transporter permease subunit	-
OANT_RS03260	658581..659399	+	819	WP_012090888.1	M55 family metallopeptidase	-
OANT_RS03265	659442..660377	+	936	WP_012090889.1	isoaspartyl peptidase/L-asparaginase	-
OANT_RS26690	660736..661023	+	288	WP_115179265.1	hypothetical protein	-
OANT_RS03275	661077..661349	+	273	WP_012090891.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
OANT_RS03280	661349..661774	+	426	WP_040130219.1	type II toxin-antitoxin system VapC family toxin	Toxin
OANT_RS03285	661785..662093	-	309	WP_012090893.1	HigA family addiction module antidote protein	-
OANT_RS03290	662242..662523	-	282	WP_041544966.1	hypothetical protein	-
OANT_RS03295	662864..664171	+	1308	WP_012090894.1	IS1380 family transposase	-
OANT_RS03300	664365..665594	-	1230	WP_115179296.1	ABC transporter substrate-binding protein	-
OANT_RS03305	665684..666553	-	870	WP_049768389.1	carbohydrate ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	636715..718762	82047
	-	flank	IS/Tn	-	-	662864..664171	1307

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-125)

Antitoxin

• Antitoxin VapB-like (1-79)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14970.04 Da
• Isoelectric Point: 4.4540

>T22320 WP_040130219.1 NC_009667:661349-661774 [Ochrobactrum anthropi ATCC 49188]
MIVDASAIIAILFDEVEAPECMDALQSDTARLISAVNYVEAGTVLAGRIREGDRHAAIADLDAFLADFGILVASIDDRLA
RAAMKARVEYGKGFGTRAGLNFGDCFAYALAKRHSAPLLYVGDDFALTDIQSALSRGPCQG

Nucleotide

• Length: 426 bp

>T22320 NC_009667:661349-661774 [Ochrobactrum anthropi ATCC 49188]
ATGATTGTCGACGCATCAGCGATCATAGCGATCCTCTTCGATGAGGTGGAAGCGCCGGAGTGCATGGATGCTCTCCAGTC
TGATACGGCGCGTCTGATATCGGCGGTGAATTACGTCGAGGCCGGTACAGTTCTTGCGGGCAGGATCAGGGAGGGAGATC
GGCATGCTGCGATTGCCGATCTGGATGCATTCCTTGCTGATTTCGGCATCTTGGTTGCGTCCATAGATGACAGGCTTGCA
CGAGCTGCGATGAAGGCGCGGGTGGAATACGGCAAGGGATTTGGAACGAGAGCCGGTTTGAACTTCGGTGATTGTTTTGC
CTATGCCTTGGCAAAACGGCATTCCGCTCCCCTTCTCTATGTCGGTGATGACTTTGCGCTGACTGACATTCAATCCGCGC
TATCACGCGGCCCCTGCCAAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10588.79 Da
• Isoelectric Point: 5.9303

>AT22320 WP_012090891.1 NC_009667:661077-661349 [Ochrobactrum anthropi ATCC 49188]
MALSIKTDEADRLARELSRLTGETMTDAITQAMRERLDRLRAEREAQRDYVARMKAFVRERASRYDRRPVTKQEWDEAVG
DTSEEPGYHQ

Nucleotide

• Length: 273 bp

>AT22320 NC_009667:661077-661349 [Ochrobactrum anthropi ATCC 49188]
ATGGCCTTGAGCATCAAGACCGATGAAGCAGACCGGTTGGCGCGGGAACTATCCCGTCTTACCGGCGAGACCATGACTGA
CGCTATCACTCAGGCCATGCGAGAGCGACTGGACCGGCTTCGTGCCGAGCGCGAGGCGCAGCGCGATTACGTTGCGCGTA
TGAAAGCTTTCGTTCGTGAGCGTGCCAGTCGTTATGACCGCCGTCCGGTTACGAAACAGGAATGGGACGAAGCCGTCGGC
GATACCTCAGAAGAGCCAGGCTATCATCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A256H0E6