Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 25419..26158 Replicon plasmid pPOL1-A
Accession NZ_CP086406
Organism Enterobacter roggenkampii strain POL1

Toxin (Protein)


Gene name tacT Uniprot ID A0A9E6WPH7
Locus tag LMJ44_RS23070 Protein ID WP_013087269.1
Coordinates 25419..25904 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A9E6WPN8
Locus tag LMJ44_RS23075 Protein ID WP_007869691.1
Coordinates 25892..26158 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMJ44_RS23040 (LMJ44_23045) 20922..21902 - 981 WP_000019445.1 IS5-like element ISKpn26 family transposase -
LMJ44_RS23045 (LMJ44_23050) 21973..22602 - 630 Protein_28 IS30-like element IS30 family transposase -
LMJ44_RS23050 (LMJ44_23055) 22599..22679 - 81 Protein_29 hypothetical protein -
LMJ44_RS23055 (LMJ44_23060) 22667..23263 + 597 Protein_30 IS3-like element ISEc52 family transposase -
LMJ44_RS23060 (LMJ44_23065) 23545..23772 + 228 Protein_31 transposase -
LMJ44_RS23065 (LMJ44_23070) 23867..25212 - 1346 Protein_32 ISNCY family transposase -
LMJ44_RS23070 (LMJ44_23075) 25419..25904 - 486 WP_013087269.1 GNAT family N-acetyltransferase Toxin
LMJ44_RS23075 (LMJ44_23080) 25892..26158 - 267 WP_007869691.1 DUF1778 domain-containing protein Antitoxin
LMJ44_RS23080 (LMJ44_23085) 26811..27824 + 1014 WP_059359379.1 plasmid replication initiator RepA -
LMJ44_RS23085 (LMJ44_23090) 28607..28906 + 300 WP_226840878.1 DUF2767 family protein -
LMJ44_RS23090 (LMJ44_23095) 28928..29695 - 768 WP_008502221.1 TraX family protein -
LMJ44_RS23095 (LMJ44_23100) 30029..30271 - 243 WP_008502222.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..85263 85263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-146)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17736.45 Da        Isoelectric Point: 9.5181

>T223194 WP_013087269.1 NZ_CP086406:c25904-25419 [Enterobacter roggenkampii]
VGRVTAPEPLSSSHQLAEFVSGEAVLDDWLKQRGLKNQALGAARTFVVCKRDTKQVVGFYSLATGSVNHVEAMGSLRRNM
PDPIPVIILARLAVDVSYRGQGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYLHHGFKASQTQERTLFLKLP
Q

Download         Length: 486 bp

>T223194 NZ_CP118567:c1081971-1081753 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACTAAAGTCGATTATTTGATGCGCCTGCGACGCTGTCAGTCAATTGACACGCTCGAACGAGT
TATTGAGAAAAATAAATACGAGCTGTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTTGCTGAAC
TGACCATGAATAAACTCTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10080.46 Da        Isoelectric Point: 4.3837

>AT223194 WP_007869691.1 NZ_CP086406:c26158-25892 [Enterobacter roggenkampii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVSDEAAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT223194 NZ_CP118567:c1082374-1082000 [Enterobacter hormaechei]
TTGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAATGAGCTGATCGAGC
ATATCGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGTCT
ATTTCGCTGCTTCACGAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References