Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3967363..3968020 Replicon chromosome
Accession NZ_CP086405
Organism Enterobacter roggenkampii strain POL1

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag LMJ44_RS18860 Protein ID WP_021242050.1
Coordinates 3967363..3967773 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag LMJ44_RS18865 Protein ID WP_006178375.1
Coordinates 3967754..3968020 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMJ44_RS18840 (LMJ44_18845) 3963356..3965089 - 1734 WP_063418239.1 single-stranded-DNA-specific exonuclease RecJ -
LMJ44_RS18845 (LMJ44_18850) 3965095..3965808 - 714 WP_063418238.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LMJ44_RS18850 (LMJ44_18855) 3965837..3966733 - 897 WP_063418237.1 site-specific tyrosine recombinase XerD -
LMJ44_RS18855 (LMJ44_18860) 3966835..3967356 + 522 WP_008499710.1 flavodoxin FldB -
LMJ44_RS18860 (LMJ44_18865) 3967363..3967773 - 411 WP_021242050.1 protein YgfX Toxin
LMJ44_RS18865 (LMJ44_18870) 3967754..3968020 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
LMJ44_RS18870 (LMJ44_18875) 3968315..3969295 + 981 WP_063418236.1 tRNA-modifying protein YgfZ -
LMJ44_RS18875 (LMJ44_18880) 3969380..3970039 - 660 WP_008499713.1 hemolysin III family protein -
LMJ44_RS18880 (LMJ44_18885) 3970305..3971036 + 732 WP_021242053.1 MurR/RpiR family transcriptional regulator -
LMJ44_RS18885 (LMJ44_18890) 3971153..3972586 + 1434 WP_023294510.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T223192 WP_021242050.1 NZ_CP086405:c3967773-3967363 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T223192 NZ_CP118553:c174564-174079 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT223192 WP_006178375.1 NZ_CP086405:c3968020-3967754 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT223192 NZ_CP118553:c174818-174552 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References