Detailed information of TA system TA223191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 3574900..3575473
• Replicon: chromosome
• Accession: NZ_CP086405
• Organism: Enterobacter roggenkampii strain POL1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LMJ44_RS16985
• Protein ID: WP_034018908.1
• Coordinates: 3574900..3575187 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LMJ44_RS16990
• Protein ID: WP_084832994.1
• Coordinates: 3575174..3575473 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LMJ44_RS16965 (LMJ44_16970)	3570337..3571368	-	1032	WP_034018910.1	hypothetical protein	-
LMJ44_RS16970 (LMJ44_16975)	3571372..3571590	-	219	WP_165690315.1	KTSC domain-containing protein	-
LMJ44_RS16975 (LMJ44_16980)	3571595..3573499	-	1905	WP_207554180.1	DUF87 domain-containing protein	-
LMJ44_RS16980 (LMJ44_16985)	3573486..3574688	-	1203	WP_079383775.1	SIR2 family protein	-
LMJ44_RS16985 (LMJ44_16990)	3574900..3575187	-	288	WP_034018908.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LMJ44_RS16990 (LMJ44_16995)	3575174..3575473	-	300	WP_084832994.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LMJ44_RS16995 (LMJ44_17000)	3575619..3575825	+	207	WP_084832993.1	hypothetical protein	-
LMJ44_RS17000 (LMJ44_17005)	3575982..3577934	-	1953	WP_084832992.1	relaxase/mobilization nuclease domain-containing protein	-
LMJ44_RS17005 (LMJ44_17010)	3577931..3578311	-	381	WP_034018902.1	conjugal transfer protein TraJ	-
LMJ44_RS17010 (LMJ44_17015)	3578656..3578898	+	243	WP_016943286.1	TraK family protein	-
LMJ44_RS17015 (LMJ44_17020)	3578990..3579199	+	210	WP_016943285.1	TraC family protein	-
LMJ44_RS17020 (LMJ44_17025)	3579202..3579426	+	225	WP_001749832.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3570337..3587615	17278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-55)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10872.32 Da
• Isoelectric Point: 4.6533

>T223191 WP_034018908.1 NZ_CP086405:c3575187-3574900 [Enterobacter roggenkampii]
VPELEWSQLARADLLAIVDYISDDNPDAAQWLKDDIEAKAAKLPEHPKLYRGGRIEGTREMVVRANYIVVYTEDSFAVRI
LRVLHAAQQWPPTQE

Nucleotide

• Length: 288 bp

>T223191 NZ_CP118553:69071-69358 [Enterobacter hormaechei]
ATGGCATATTTTCTGGATTTTGACGAGCGTGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGCTAAA
AAATAAGTTGGCTGAAGTGCTTGAGTCACCCCGAATTGATGCGAACAAGCTTCGGGGTATGCATGACTGTTACAAAATTA
AGCTCCGGTCTTCAGGCTATCGTCTTGTATATCAGGTCATAGACGAGAAGGTTGTCGTCTTTGTGATTTCTGTCGGGAAA
AGAGAGCGCTCGGAAGTTTATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11015.50 Da
• Isoelectric Point: 6.8812

>AT223191 WP_084832994.1 NZ_CP086405:c3575473-3575174 [Enterobacter roggenkampii]
MAAQTSMLHIRVDDKLKADATEKLANVGLSVSDAVRIFLTRVTKEGGLPVGLTTDPEAHDKWFRAKVHEALSDSQPDVPH
QQVMDEAQDLIDRKRRARA

Nucleotide

• Length: 300 bp

>AT223191 NZ_CP118553:68832-69071 [Enterobacter hormaechei]
ATGGGTAGCATCAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCTGCGCTTGAAAAAATGGGTGTAACTCC
CTCTGAGGCACTTCGCCTCATGCTTGAATATATTGCTGACAATGAACGTTTGCCGTTCAAACAGACACTCCTGAGTGATG
AGGATGCTGAGCTCGTGGAGATCGTGAAAGAACGACTTCGCAATCCTAAGCCAGTACGTGTGACGCTGGATGAGCTCTGA