Detailed information of TA system TA022319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 647913..648511
• Replicon: chromosome
• Accession: NC_009667
• Organism: Ochrobactrum anthropi ATCC 49188

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: OANT_RS26685
• Protein ID: WP_158304319.1
• Coordinates: 648227..648511 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: A0A256GNU9
• Locus tag: OANT_RS03190
• Protein ID: WP_041545288.1
• Coordinates: 647913..648227 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OANT_RS03185	643345..646803	+	3459	WP_012090874.1	chromosome segregation protein SMC	-
OANT_RS26680	646908..647054	+	147	WP_158304318.1	hypothetical protein	-
OANT_RS03190	647913..648227	-	315	WP_041545288.1	BrnA antitoxin family protein	Antitoxin
OANT_RS26685	648227..648511	-	285	WP_158304319.1	hypothetical protein	Toxin
OANT_RS03200	648690..649871	+	1182	WP_012090877.1	Fic family protein	-
OANT_RS03205	650031..650306	+	276	Protein_630	PIN domain-containing protein	-
OANT_RS03210	650303..650557	+	255	WP_012090879.1	toxin-antitoxin system HicB family antitoxin	-
OANT_RS03215	650859..651285	+	427	Protein_632	type IV secretory system conjugative DNA transfer family protein	-
OANT_RS26970	651440..651601	-	162	WP_140986072.1	toxin-antitoxin system HicB family antitoxin	-
OANT_RS03225	651769..652023	-	255	WP_041544962.1	type II toxin-antitoxin system HicA family toxin	-
OANT_RS03230	652037..652252	-	216	WP_094513475.1	hypothetical protein	-
OANT_RS03235	652409..653302	+	894	WP_012090883.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	636715..718762	82047

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (28-102)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10840.76 Da
• Isoelectric Point: 10.8134

>T22319 WP_158304319.1 NC_009667:c648511-648227 [Ochrobactrum anthropi ATCC 49188]
MSQSVEFMLLKTQWYLSRNWIRAKWKTGSNSIETQHLHLEFFLSAKVFPTKADRLMAIGEFNGQIIIVVVFKPIGSEALS
VISMRPASQKERKL

Nucleotide

• Length: 285 bp

>T22319 NC_009667:c648511-648227 [Ochrobactrum anthropi ATCC 49188]
ATGTCCCAGTCAGTTGAATTCATGCTCTTGAAAACACAATGGTATCTGTCTCGCAATTGGATCAGAGCGAAATGGAAAAC
TGGTTCAAACTCAATTGAAACTCAACACTTGCATTTAGAATTCTTCTTGTCGGCCAAGGTCTTCCCTACCAAGGCAGATC
GCTTGATGGCAATCGGCGAATTCAACGGTCAGATCATTATCGTCGTCGTCTTCAAGCCGATTGGTTCGGAAGCCCTCTCC
GTTATCTCCATGCGTCCAGCAAGCCAAAAGGAAAGGAAGCTATGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11605.44 Da
• Isoelectric Point: 10.3131

>AT22319 WP_041545288.1 NC_009667:c648227-647913 [Ochrobactrum anthropi ATCC 49188]
MGIKFSSKRPLTQEEEAAIQKMIASDPDAPEATDEQLAKAKPFKEALPEMAAKMEKAIRGRPRIDDPKTPVTIRLDQDVV
QRFKATGKGWQSRMNEALRKAVGL

Nucleotide

• Length: 315 bp

>AT22319 NC_009667:c648227-647913 [Ochrobactrum anthropi ATCC 49188]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGCAATCCAGAAGATGATCGCAAGTGATCC
TGATGCGCCAGAAGCCACCGATGAACAACTTGCCAAGGCAAAACCCTTCAAAGAAGCCCTCCCGGAAATGGCCGCCAAGA
TGGAGAAGGCCATTCGGGGCCGACCGCGTATCGACGATCCCAAGACACCGGTTACGATCCGGCTCGATCAGGATGTGGTT
CAACGCTTCAAGGCTACTGGCAAAGGTTGGCAGAGCCGCATGAATGAGGCTCTGCGCAAGGCTGTTGGCCTATAA

Structures

Antitoxin

• AlphaFold DB: A0A256GNU9