Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 257306..257902 Replicon chromosome
Accession NZ_CP086405
Organism Enterobacter roggenkampii strain POL1

Toxin (Protein)


Gene name PumA Uniprot ID A0A0F1DED9
Locus tag LMJ44_RS01165 Protein ID WP_023293553.1
Coordinates 257600..257902 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag LMJ44_RS01160 Protein ID WP_021242718.1
Coordinates 257306..257593 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMJ44_RS01155 (LMJ44_01160) 255678..257309 + 1632 WP_008503411.1 Na/Pi cotransporter family protein -
LMJ44_RS01160 (LMJ44_01165) 257306..257593 - 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
LMJ44_RS01165 (LMJ44_01170) 257600..257902 - 303 WP_023293553.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMJ44_RS01170 (LMJ44_01175) 258100..258972 + 873 WP_008503414.1 23S rRNA pseudouridine(2604) synthase RluF -
LMJ44_RS01175 (LMJ44_01180) 258973..259245 - 273 WP_059360216.1 DUF3811 domain-containing protein -
LMJ44_RS01180 (LMJ44_01185) 259296..260240 - 945 WP_023293551.1 ketopantoate/pantoate/pantothenate transporter PanS -
LMJ44_RS01185 (LMJ44_01190) 260346..261920 - 1575 WP_063418185.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11459.24 Da        Isoelectric Point: 10.1771

>T223179 WP_023293553.1 NZ_CP086405:c257902-257600 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

>T223179 NZ_CP118547:307105-307407 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTGCCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT223179 WP_021242718.1 NZ_CP086405:c257593-257306 [Enterobacter roggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp

>AT223179 NZ_CP118547:306759-307064 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F1DED9

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References