Detailed information of TA system TA223173

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-ChpS
• Location: 3850948..3851543
• Replicon: chromosome
• Accession: NZ_CP086391
• Organism: Escherichia coli strain 1585m1

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: -
• Locus tag: LM401_RS20865
• Protein ID: WP_105960578.1
• Coordinates: 3850948..3851298 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: U9Y2K1
• Locus tag: LM401_RS20870
• Protein ID: WP_001223208.1
• Coordinates: 3851292..3851543 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LM401_RS20845 (3846224)	3846224..3847246	-	1023	WP_001339490.1	ABC transporter permease	-
LM401_RS20850 (3847260)	3847260..3848762	-	1503	WP_000205793.1	sugar ABC transporter ATP-binding protein	-
LM401_RS20855 (3849072)	3849072..3850028	-	957	WP_000265933.1	galactofuranose ABC transporter substrate-binding protein YtfQ	-
LM401_RS20860 (3850338)	3850338..3850868	+	531	WP_000055072.1	inorganic diphosphatase	-
LM401_RS20865 (3850948)	3850948..3851298	-	351	WP_105960578.1	endoribonuclease toxin ChpB	Toxin
LM401_RS20870 (3851292)	3851292..3851543	-	252	WP_001223208.1	type II toxin-antitoxin system antitoxin ChpS	Antitoxin
LM401_RS20875 (3851756)	3851756..3852097	-	342	WP_001219160.1	gamma-glutamylcyclotransferase	-
LM401_RS20880 (3852100)	3852100..3855879	-	3780	WP_000060901.1	autotransporter assembly complex protein TamB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (8-114)

Antitoxin

• SpoVT-AbrB domain (6-49)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12537.48 Da
• Isoelectric Point: 5.1253

>T223173 WP_105960578.1 NZ_CP086391:c3851298-3850948 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGYEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Nucleotide

• Length: 351 bp

>T223173 NZ_CP118543:c51866-51438 [Salmonella sp. CVCC 1806]
ATGAAACAGCCACGTACGAAGACCTATATGCTCGATACCTGTATCTGTTCGTTCATCATGCGCGAGAAGTCGGAAGCGGT
GCTGAAGCGCCTTGAGCAGGCGGTGCTGCGCGGCCACCGTATCGTGATCTCGGCCATCACCTACTCCGAGATGCGCTTCG
GCGCCACCGGACCTAAGGCCTCGCCGCGTCTCGTCCAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCC
TGGGATCGCGCTGCGGTAGACGCCACCACGGAGATTAAGGTGGCACTGTGCCTCGCCGGGACGCCGATCGGTCCGAACGA
CACGGCGATTGCCGGGCATGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGG
GCCTGGTACTGGAAGACTGGGTAAGTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9271.58 Da
• Isoelectric Point: 4.4201

>AT223173 WP_001223208.1 NZ_CP086391:c3851543-3851292 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Nucleotide

• Length: 252 bp

>AT223173 NZ_CP118543:c52093-51863 [Salmonella sp. CVCC 1806]
ATGAGAACCGTATCCATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGCTTTGAGCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U9LQ26