Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2100619..2101257 Replicon chromosome
Accession NZ_CP086391
Organism Escherichia coli strain 1585m1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag LM401_RS12425 Protein ID WP_000813794.1
Coordinates 2101081..2101257 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LM401_RS12420 Protein ID WP_001270286.1
Coordinates 2100619..2101035 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LM401_RS12400 (2095771) 2095771..2096712 - 942 WP_001251319.1 ABC transporter permease -
LM401_RS12405 (2096713) 2096713..2097726 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
LM401_RS12410 (2097744) 2097744..2098889 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
LM401_RS12415 (2099134) 2099134..2100540 - 1407 WP_000760629.1 PLP-dependent aminotransferase family protein -
LM401_RS12420 (2100619) 2100619..2101035 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
LM401_RS12425 (2101081) 2101081..2101257 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
LM401_RS12430 (2101479) 2101479..2101709 + 231 WP_000494244.1 YncJ family protein -
LM401_RS12435 (2101801) 2101801..2103762 - 1962 WP_001307191.1 23S rRNA 5-hydroxycytidine C2501 synthase -
LM401_RS12440 (2103835) 2103835..2104371 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
LM401_RS12445 (2104463) 2104463..2105638 + 1176 WP_001236319.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2105678..2106943 1265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T223168 WP_000813794.1 NZ_CP086391:c2101257-2101081 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T223168 NZ_CP118542:c4047466-4047158 [Salmonella sp. CVCC 1806]
ATGCAATACATGGTTTATCACAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT223168 WP_001270286.1 NZ_CP086391:c2101035-2100619 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT223168 NZ_CP118542:c4047708-4047469 [Salmonella sp. CVCC 1806]
ATGCCAGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCATGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References