Detailed information of TA system TA022315

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /DUF1778(antitoxin)
• Location: 867500..868296
• Replicon: chromosome
• Accession: NC_009665
• Organism: Shewanella baltica OS185

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: SHEW185_RS03730
• Protein ID: WP_012088252.1
• Coordinates: 867766..868296 (+)
• Length: 177 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A3D8P1
• Locus tag: SHEW185_RS03725
• Protein ID: WP_011847802.1
• Coordinates: 867500..867769 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SHEW185_RS03705	862816..865008	+	2193	WP_012088249.1	TonB-dependent siderophore receptor	-
SHEW185_RS03710	865109..865783	+	675	WP_006086056.1	Fe2+-dependent dioxygenase	-
SHEW185_RS03715	866221..866706	+	486	WP_012088251.1	hypothetical protein	-
SHEW185_RS03720	866837..867301	+	465	WP_041411001.1	hypothetical protein	-
SHEW185_RS03725	867500..867769	+	270	WP_011847802.1	DUF1778 domain-containing protein	Antitoxin
SHEW185_RS03730	867766..868296	+	531	WP_012088252.1	GNAT family N-acetyltransferase	Toxin
SHEW185_RS03735	868852..869625	+	774	WP_012088253.1	hypothetical protein	-
SHEW185_RS03740	869615..870019	+	405	WP_012088254.1	hypothetical protein	-
SHEW185_RS23890	870068..870241	+	174	WP_198136737.1	hypothetical protein	-
SHEW185_RS03750	870307..870600	-	294	WP_041411002.1	hypothetical protein	-
SHEW185_RS03755	870597..870917	-	321	WP_012088256.1	hypothetical protein	-
SHEW185_RS03760	870914..871522	-	609	WP_012088257.1	hypothetical protein	-
SHEW185_RS03765	871519..871749	-	231	WP_012088258.1	hypothetical protein	-
SHEW185_RS03770	871746..872024	-	279	WP_012088259.1	hypothetical protein	-
SHEW185_RS03775	872025..872318	-	294	WP_012088260.1	hypothetical protein	-
SHEW185_RS03780	872349..872696	-	348	WP_006082041.1	hypothetical protein	-
SHEW185_RS03785	872722..872982	-	261	WP_012088261.1	pyocin activator PrtN family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	857753..908180	50427

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (96-155)

Antitoxin

• Vibrio phage ICP1, Orf50 (5-81)

Sequences

Toxin

Protein

• Length: 177 a.a.
• Molecular weight: 19762.02 Da
• Isoelectric Point: 8.4733

>T22315 WP_012088252.1 NC_009665:867766-868296 [Shewanella baltica OS185]
VSYSKTFKELDKSQHDRASFDCGEAELNDFIQTQAAKHMQAGISRTMVLPACTPLPNQKYPICSFYTIAPSSICRDTLPQ
AMGKKLPRYPIPVFLLAQLAVHKEFHGSGLGKASLIKALEYLWEINAHMRAYAIVVDCLTSQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT

Nucleotide

• Length: 531 bp

>T22315 NC_009665:867766-868296 [Shewanella baltica OS185]
GTGAGTTACTCCAAGACTTTTAAAGAATTGGATAAATCACAACACGATAGAGCATCATTTGACTGTGGCGAAGCAGAGTT
AAACGATTTTATCCAAACTCAAGCAGCGAAACACATGCAGGCAGGTATTAGCCGTACAATGGTTTTACCTGCTTGTACGC
CATTGCCCAATCAAAAATATCCAATTTGCTCATTTTATACTATCGCACCAAGTTCAATTTGCCGTGATACCTTGCCGCAA
GCCATGGGTAAAAAGTTACCACGCTATCCCATTCCGGTTTTTCTGCTTGCTCAACTTGCGGTCCATAAAGAGTTTCATGG
TAGTGGGTTAGGTAAAGCTAGCTTAATCAAAGCGCTAGAATATCTTTGGGAAATTAACGCTCACATGCGAGCTTATGCCA
TTGTTGTCGATTGTTTAACTAGCCAAGCTGAATCATTCTATGCCAAGTATGGTTTCGAGGTTCTTTGTGAAATCAACGGT
CGTGTCAGAATGTTTATTCCAATGAAAACAGTCGGTCAGTTATTCACTTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9889.35 Da
• Isoelectric Point: 4.8949

>AT22315 WP_011847802.1 NC_009665:867500-867769 [Shewanella baltica OS185]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDSTQVIAEHESITVKADVFDQFIMACDEAKAPNKALREAA
AFTKRGDFK

Nucleotide

• Length: 270 bp

>AT22315 NC_009665:867500-867769 [Shewanella baltica OS185]
ATGGCGACTGCAAGACTTGATATCCGTTTGGATGAAGAGATCAAAGCTAAGGCTGAGAAAGCATCGGCTTTGCTTGGGTT
AAAAAGCTTAACTGAATACGTTGTTCGCTTAATGGACGAAGATTCAACTCAGGTGATTGCTGAGCATGAAAGCATTACTG
TTAAAGCTGATGTATTCGACCAATTCATAATGGCTTGTGATGAGGCTAAGGCCCCGAACAAGGCATTGCGTGAAGCGGCA
GCATTTACTAAACGTGGTGACTTTAAGTGA

Structures

Antitoxin

• AlphaFold DB: A3D8P1