Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 1248244..1248830 Replicon chromosome
Accession NZ_CP086380
Organism Deinococcus radiophilus strain ATCC 27603

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LMT64_RS06275 Protein ID WP_126350959.1
Coordinates 1248244..1248612 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LMT64_RS06280 Protein ID WP_126350960.1
Coordinates 1248609..1248830 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMT64_RS06260 (LMT64_06260) 1243801..1245729 + 1929 WP_229253083.1 acetate--CoA ligase -
LMT64_RS06265 (LMT64_06265) 1245846..1246985 + 1140 WP_170165890.1 tetratricopeptide repeat protein -
LMT64_RS06270 (LMT64_06270) 1247081..1248247 - 1167 WP_126350958.1 nitrilase-related carbon-nitrogen hydrolase -
LMT64_RS06275 (LMT64_06275) 1248244..1248612 - 369 WP_126350959.1 DUF5615 family PIN-like protein Toxin
LMT64_RS06280 (LMT64_06280) 1248609..1248830 - 222 WP_126350960.1 DUF433 domain-containing protein Antitoxin
LMT64_RS06285 (LMT64_06285) 1248936..1249109 + 174 WP_170165891.1 hypothetical protein -
LMT64_RS06290 (LMT64_06290) 1249195..1249758 - 564 WP_126350961.1 hypothetical protein -
LMT64_RS06295 (LMT64_06295) 1249745..1250194 - 450 WP_126350962.1 hypothetical protein -
LMT64_RS06300 (LMT64_06300) 1250445..1251782 - 1338 WP_126350963.1 acetyl-CoA carboxylase biotin carboxylase subunit -
LMT64_RS06305 (LMT64_06305) 1251867..1252406 - 540 WP_126350964.1 acetyl-CoA carboxylase biotin carboxyl carrier protein -
LMT64_RS06310 (LMT64_06310) 1252566..1253123 - 558 WP_126350965.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(14-89)

Antitoxin

Protein of unknown function DUF433

(7-62)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13436.44 Da        Isoelectric Point: 4.7118

>T223143 WP_126350959.1 NZ_CP086380:c1248612-1248244 [Deinococcus radiophilus]
MRYEQRGDLHLGPLWLDAHLPPALAPWLRETFGIEAYSAAYLGLRDAEDAAIFAQAREAGAVIVSKDADFLERVVRLGPP
PRLIYLTCGNTSKAALKILFERQFEQIAILLESGEAVVEVSG

Download         Length: 369 bp

>T223143 NZ_CP118538:c33704-33426 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCATCCCCATTTTGTTCTGGTTTATGAAGTCGATAGCCAGTGGGGTAAAGTGTAT
ATCCTGCGCGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8158.34 Da        Isoelectric Point: 4.7004

>AT223143 WP_126350960.1 NZ_CP086380:c1248830-1248609 [Deinococcus radiophilus]
MSLLDRITVNPQQCGGRPCIRGMRIRVSDILDLLGAGVEVEEILADHPDLEREDVYAALTWAARYVDHPRLSA

Download         Length: 222 bp

>AT223143 NZ_CP118538:c33973-33704 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGTGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCCGCTGCATGGCGGGAT
GAAATGCGCAGGAAGGTTGCCGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References