Detailed information of TA system TA223141

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3987110..3987666
• Replicon: chromosome
• Accession: NZ_CP086372
• Organism: Xanthomonas oryzae pv. oryzae strain GXO2001

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LNP58_RS18760
• Protein ID: WP_229001948.1
• Coordinates: 3987415..3987666 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: LNP58_RS18755
• Protein ID: WP_011408759.1
• Coordinates: 3987110..3987388 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LNP58_RS18735 (LNP58_18700)	3982227..3982784	-	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-
LNP58_RS18740 (LNP58_18705)	3982934..3983899	-	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
LNP58_RS18745 (LNP58_18710)	3984480..3985664	+	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
LNP58_RS18750 (LNP58_18715)	3986570..3986914	+	345	WP_199285675.1	hypothetical protein	-
LNP58_RS18755 (LNP58_18720)	3987110..3987388	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
LNP58_RS18760 (LNP58_18725)	3987415..3987666	+	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LNP58_RS18765 (LNP58_18730)	3987927..3988124	+	198	WP_153296741.1	hypothetical protein	-
LNP58_RS18770 (LNP58_18735)	3988193..3988447	+	255	WP_223293127.1	hypothetical protein	-
LNP58_RS18775 (LNP58_18740)	3988664..3988783	+	120	Protein_3599	IS3 family transposase	-
LNP58_RS23440	3988752..3988880	+	129	WP_012444694.1	hypothetical protein	-
LNP58_RS18785 (LNP58_18750)	3989311..3989712	-	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
LNP58_RS18790 (LNP58_18755)	3989934..3990110	+	177	Protein_3602	DUF3606 domain-containing protein	-
LNP58_RS18795 (LNP58_18760)	3990392..3990729	+	338	Protein_3603	ATP-dependent DNA ligase	-
LNP58_RS18800 (LNP58_18765)	3990805..3991896	-	1092	WP_041182166.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T223141 WP_229001948.1 NZ_CP086372:3987415-3987666 [Xanthomonas oryzae pv. oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T223141 NZ_CP118537:c4533820-4533446 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAAAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
CAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT223141 WP_011408759.1 NZ_CP086372:3987110-3987388 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT223141 NZ_CP118537:c4534062-4533820 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2