Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 790845..792386 Replicon chromosome
Accession NC_009665
Organism Shewanella baltica OS185

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag SHEW185_RS03350 Protein ID WP_012088210.1
Coordinates 791085..792386 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag SHEW185_RS03345 Protein ID WP_006086108.1
Coordinates 790845..791081 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SHEW185_RS03325 786860..787854 - 995 Protein_642 IS110 family transposase -
SHEW185_RS03330 788274..789449 + 1176 WP_006086111.1 HEAT repeat domain-containing protein -
SHEW185_RS03335 789501..789686 - 186 WP_006086110.1 hypothetical protein -
SHEW185_RS03340 789762..790001 - 240 WP_006086109.1 esterase -
SHEW185_RS03345 790845..791081 + 237 WP_006086108.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
SHEW185_RS03350 791085..792386 + 1302 WP_012088210.1 HipA domain-containing protein Toxin
SHEW185_RS23085 793515..794090 + 576 WP_012088211.1 hypothetical protein -
SHEW185_RS03360 794208..794357 + 150 WP_041410993.1 4-carboxymuconolactone decarboxylase -
SHEW185_RS03365 794438..794689 - 252 WP_012088212.1 DUF2999 family protein -
SHEW185_RS03370 794857..796353 + 1497 WP_012088213.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48529.70 Da        Isoelectric Point: 5.3107

>T22314 WP_012088210.1 NC_009665:791085-792386 [Shewanella baltica OS185]
MSTSKKLTLEMHLGDLMIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTASSSQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GEEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYIPNAQKVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAAKCRNPVAAKQDMLQWALFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLGLPRNLLISNLTTIARRIPQAIDGVISMLPPLD
EDEASFVAHYKAQLLARCDRYFSFAADVRDVEV

Download         Length: 1302 bp

>T22314 NC_009665:791085-792386 [Shewanella baltica OS185]
ATGAGTACTTCCAAAAAGCTCACGTTAGAGATGCACCTCGGTGATTTAATGATCGGGGAGTTATCCTTTGATGCGACGAC
CGACACCTTTGCCGTACATTACACCAAAGACTGGCAACAAAGTGGATTCCCACTATCCCCAACAATTCCCTTAGATGGCA
CAGCAAGTAGCAGTCAGATATCGATGTTTTTGGTTAACTTATTACCGGAAAACAAAGGATTAGATTATCTAATTGAATCC
CTTGGCGTCTCCAAGGGAAATACCTTTGCCTTGATCCGCGCCATTGGTCTCGATACTGCAGGTGCTGTTGCTTTTGTTCC
TAAAGGGACTTTGCTGCCTGAAACACAATTACGGCCAATTAAGGCTGAAGAAGTTATTCAGCGAATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTGTCGGTAGCGGGTGTACAACCTAAATTAAACCTGTTTTATAAC
GGTGAAGAATTTGCATTTGCCGAAGGCGCACTGTCATCTACCCATATTGTTAAATTCGAAAAATATCGCCATTTAGTGCT
CAATGAATTTATGACGATGCGCTTAGCCAAGGCGATTGGAATGAATGTGGCTAATGTTGATATCGTTCATTTTGGAGATT
ACAAAGTACTCTGTGTCGAACGCTTTGACCGACGTTATATACCAAATGCGCAAAAGGTATTAAGAAGACATATTGTCGAT
AGCTGCCAAGCTCTTGGTTTTAGTGTTAGCAAAAAATATGAACGTAATTTTGGTTCAGGGCGTGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAACAGGCTCTTTAGTCTCGCAGCAAAATGCCGTAATCCAGTGGCCGCTAAGCAGGATATGTTGC
AGTGGGCGCTATTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTACTCATTTTTTATGACGCCAAGCGGA
ATGGAGCCAACCCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCGATGGCAATTGA
TGACGAATTTGATCCAAATAGCATTTACGCGTATCAATTGGCTGCATTTATTGATGGCTTAGGTTTACCAAGAAATTTAT
TAATCAGTAACTTAACGACAATAGCGCGAAGAATACCGCAGGCAATAGATGGTGTGATTTCAATGCTCCCGCCCCTTGAT
GAAGATGAAGCATCATTTGTGGCTCATTACAAAGCGCAGTTGCTGGCGAGATGTGATCGTTACTTTAGTTTTGCCGCCGA
TGTCAGGGATGTGGAAGTGTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8574.91 Da        Isoelectric Point: 7.9728

>AT22314 WP_006086108.1 NC_009665:790845-791081 [Shewanella baltica OS185]
MASRLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIEIVSAQTSDTETNGWY

Download         Length: 237 bp

>AT22314 NC_009665:790845-791081 [Shewanella baltica OS185]
ATGGCATCACGGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGAAGGAAAAGTGCTGCTCTTACTCAAGACGT
GGCAGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAAGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTTGATGGTCTGGGGATTGAGATCGTTTCGGCTCAAACCAGCGACACCGAAACTAACGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References