Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 6719438..6721223 Replicon chromosome
Accession NZ_CP086370
Organism Massilia sp. HC52

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag KT882_RS30030 Protein ID WP_161071042.1
Coordinates 6719438..6720361 (+) Length 308 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag KT882_RS30035 Protein ID WP_161071043.1
Coordinates 6720387..6721223 (+) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KT882_RS30000 6714924..6715214 + 291 WP_161071038.1 hypothetical protein -
KT882_RS30005 6715472..6716263 + 792 WP_228894023.1 ABC transporter ATP-binding protein -
KT882_RS30010 6716333..6717271 + 939 WP_228896805.1 ABC transporter substrate-binding protein -
KT882_RS30015 6717272..6718108 + 837 WP_228894024.1 ABC transporter permease -
KT882_RS30020 6718120..6718881 + 762 WP_228894025.1 SDR family oxidoreductase -
KT882_RS30025 6718897..6719436 + 540 WP_161071041.1 cupin domain-containing protein -
KT882_RS30030 6719438..6720361 + 924 WP_161071042.1 alpha/beta hydrolase Toxin
KT882_RS30035 6720387..6721223 + 837 WP_161071043.1 IclR family transcriptional regulator Antitoxin
KT882_RS30040 6721260..6722063 + 804 WP_161071044.1 SDR family oxidoreductase -
KT882_RS30045 6722056..6723738 + 1683 WP_228894026.1 thiamine pyrophosphate-binding protein -
KT882_RS30050 6723748..6724548 + 801 WP_161071046.1 aspartate dehydrogenase -
KT882_RS30055 6724559..6726043 + 1485 WP_228894027.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(60-304)

Antitoxin

ArsR-like helix-turn-helix domain

(25-94)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 31525.91 Da        Isoelectric Point: 6.8150

>T223136 WP_161071042.1 NZ_CP086370:6719438-6720361 [Massilia sp. HC52]
MNFAGISAKAPEADGLQYALSLLERHFAEQTVAVEGGAVSYREIAPAPGVPPAPATQSAIVLLHGIGSGAASWLPCALEL
AAAAPGARIIAWNAPGYGASTPLPAARPGADAYAARLRQMLQALGVLGAHDSGRITLVGHSLGAMMASAYAAAHPATLDK
LVLLSPARGYGQAARLEQGAQVARERLSTVGELGVHGMATQRSARLLSGNATTAQRDWVRWNMAQLNLAGYTQAVHLLCG
DAIENYALSGAVCAVASVHCGSADNVTTPDDCRLVAERHGLPFALIDQAGHACYVEQPSAAMAAILN

Download         Length: 924 bp

>T223136 NZ_CP118537:c2784106-2784004 [Salmonella enterica subsp. enterica serovar Typhi]
GCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 31170.51 Da        Isoelectric Point: 6.0563

>AT223136 WP_161071043.1 NZ_CP086370:6720387-6721223 [Massilia sp. HC52]
MNNKPEQAEDDSADKYTVPGLERGLRLLCEFSRNEKTLSAPELAKRLDVPRSTVFRLLTTLERMGFVERAEGGRDYRLGM
AVLRMGFEYLASLELTEIGRPLLERLRDEIGYSTTLVVRDARNIVYVAKSSTPAPFVSTVNVGTRLPAHATVLGRVLLQD
LTLPQLRELYPEEHLKVYSDSTPHTVLDLFNLLQQDRERGYVWEQGFFERGISTMAAPVRDHSGKVVAALGATIPDQNIG
GEQLERIVAQVRGSAGELSRLLDHAPTETAQIVNLWQR

Download         Length: 837 bp

>AT223136 NZ_CP118537:2784002-2784145 [Salmonella enterica subsp. enterica serovar Typhi]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCTCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References