Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 5017170..5017807 Replicon chromosome
Accession NZ_CP086370
Organism Massilia sp. HC52

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KT882_RS22320 Protein ID WP_161074679.1
Coordinates 5017406..5017807 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KT882_RS22315 Protein ID WP_161074680.1
Coordinates 5017170..5017406 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KT882_RS22285 5012200..5012631 + 432 WP_228893351.1 YeeE/YedE family protein -
KT882_RS22290 5012651..5013067 + 417 WP_161074721.1 YeeE/YedE family protein -
KT882_RS22295 5013153..5014811 + 1659 WP_161074720.1 acid phosphatase -
KT882_RS22300 5014920..5015144 + 225 WP_161074683.1 hypothetical protein -
KT882_RS22305 5015241..5016653 + 1413 WP_161074682.1 ATP-dependent RNA helicase DbpA -
KT882_RS22310 5016713..5017099 + 387 WP_161074681.1 VOC family protein -
KT882_RS22315 5017170..5017406 + 237 WP_161074680.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KT882_RS22320 5017406..5017807 + 402 WP_161074679.1 type II toxin-antitoxin system VapC family toxin Toxin
KT882_RS22325 5017855..5018055 - 201 WP_161074678.1 hypothetical protein -
KT882_RS22330 5018133..5018768 + 636 WP_161074677.1 hemolysin III family protein -
KT882_RS22335 5018881..5019291 - 411 WP_228893352.1 hypothetical protein -
KT882_RS22340 5019367..5020320 - 954 WP_161074675.1 chemotaxis protein -
KT882_RS22345 5020390..5021349 - 960 WP_228893353.1 threo-3-hydroxy-L-aspartate ammonia-lyase -
KT882_RS22350 5021379..5022347 - 969 WP_228893354.1 ornithine cyclodeaminase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15063.50 Da        Isoelectric Point: 6.9507

>T223135 WP_161074679.1 NZ_CP086370:5017406-5017807 [Massilia sp. HC52]
MPLYMLDTNMCIYLMKNQPAQVSERFSQCYVGDVVMSAITYAELEYGVEISANSMRERRNLAALVEDIPVAAFNMAAAKA
YGPVRAAARERKRDQLDKLIAAHAIALDVILVTNNEKDFARYPSLKMENWLRI

Download         Length: 402 bp

>T223135 NZ_CP118537:c1418069-1417851 [Salmonella enterica subsp. enterica serovar Typhi]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9050.31 Da        Isoelectric Point: 8.6588

>AT223135 WP_161074680.1 NZ_CP086370:5017170-5017406 [Massilia sp. HC52]
MKTTKLFRNGNSQAVRIPSELAYERTDMELEIERVGEELRIRPARRPLTGVLKKFARFGPDFMSEGRGDQEQAEREPI

Download         Length: 237 bp

>AT223135 NZ_CP118537:c1418471-1418097 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References