Detailed information of TA system TA223134

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 4295023..4295648
• Replicon: chromosome
• Accession: NZ_CP086370
• Organism: Massilia sp. HC52

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KT882_RS19100
• Protein ID: WP_228893050.1
• Coordinates: 4295023..4295277 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KT882_RS19105
• Protein ID: WP_161073112.1
• Coordinates: 4295274..4295648 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KT882_RS19065	4290186..4290527	-	342	WP_228893048.1	hypothetical protein	-
KT882_RS19070	4290635..4291096	-	462	WP_228893049.1	DUF4440 domain-containing protein	-
KT882_RS19075	4291141..4291794	-	654	WP_161073118.1	hydrolase	-
KT882_RS19080	4291980..4292417	+	438	WP_161073117.1	MbcA/ParS/Xre antitoxin family protein	-
KT882_RS19085	4292417..4293103	+	687	WP_187358736.1	RES family NAD+ phosphorylase	-
KT882_RS19090	4293112..4293432	+	321	WP_161073115.1	DUF2288 domain-containing protein	-
KT882_RS19095	4293451..4294827	-	1377	WP_161073114.1	YihY family inner membrane protein	-
KT882_RS19100	4295023..4295277	+	255	WP_228893050.1	type II toxin-antitoxin system HicA family toxin	Toxin
KT882_RS19105	4295274..4295648	+	375	WP_161073112.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KT882_RS19110	4295658..4296266	+	609	WP_161073111.1	NAD(P)H:quinone oxidoreductase	-
KT882_RS19115	4296266..4296676	+	411	WP_161073220.1	DUF2069 domain-containing protein	-
KT882_RS19120	4296673..4298118	+	1446	WP_228893051.1	FAD-binding oxidoreductase	-
KT882_RS19125	4298115..4298546	+	432	WP_161073110.1	DUF4124 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (56-105)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9193.70 Da
• Isoelectric Point: 10.3922

>T223134 WP_228893050.1 NZ_CP086370:4295023-4295277 [Massilia sp. HC52]
MKAKHQRTLQLIFSRPTPAGVKWLDAVALLEARGADISEAEGSRVAVCLFGQVKVLHRPHPSPDIDKGAVASIRKWLEEN
GVKP

Nucleotide

• Length: 255 bp

>T223134 NZ_CP118537:c1003710-1003183 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACAAAAACCTACGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13304.12 Da
• Isoelectric Point: 4.8605

>AT223134 WP_161073112.1 NZ_CP086370:4295274-4295648 [Massilia sp. HC52]
MNNIMKIDGQQAVIAYDPEIELFRGEFIGLNGGADFYAPDVAGLQREGSISLAVFLRTCKERGIEPFKSFSGKFVLRVDP
AVHEAAALAAAADGKSLNQWASDVLKISLEAADNSYASPRAKLA

Nucleotide

• Length: 375 bp

>AT223134 NZ_CP118537:c1003997-1003707 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGATTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA