Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1241075..1241739 Replicon chromosome
Accession NZ_CP086370
Organism Massilia sp. HC52

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KT882_RS05445 Protein ID WP_228894779.1
Coordinates 1241075..1241488 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KT882_RS05450 Protein ID WP_228894780.1
Coordinates 1241485..1241739 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KT882_RS05430 1236566..1236907 - 342 WP_267478639.1 DUF1840 domain-containing protein -
KT882_RS05435 1237058..1237891 - 834 WP_228894774.1 type 1 glutamine amidotransferase domain-containing protein -
KT882_RS05440 1238030..1240972 - 2943 WP_228894778.1 sensor histidine kinase -
KT882_RS05445 1241075..1241488 - 414 WP_228894779.1 type II toxin-antitoxin system VapC family toxin Toxin
KT882_RS05450 1241485..1241739 - 255 WP_228894780.1 plasmid stabilization protein Antitoxin
KT882_RS05460 1242059..1243027 + 969 WP_161074146.1 MYG1 family protein -
KT882_RS05465 1243093..1243761 - 669 WP_228894781.1 PEP-CTERM sorting domain-containing protein -
KT882_RS05470 1244025..1245479 + 1455 WP_228894782.1 serine hydrolase -
KT882_RS05475 1245495..1246433 - 939 WP_228894784.1 beta-lactamase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1241075..1249222 8147


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14641.88 Da        Isoelectric Point: 6.4802

>T223131 WP_228894779.1 NZ_CP086370:c1241488-1241075 [Massilia sp. HC52]
MIILDTNVISEAMKAAPHPAVQAWLNNQAAETLYLSSVTLAELLFGIHSLPAGKRQDLLTRALDALLGLFKGRILPFDTD
AARHYAELAVAAKAAGHGFPMPDSYIAAIADSRKFIVASRDTAPYEAAGLTVVNPWA

Download         Length: 414 bp

>T223131 NZ_CP118537:231415-231900 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGACGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 5.7252

>AT223131 WP_228894780.1 NZ_CP086370:c1241739-1241485 [Massilia sp. HC52]
MAMLTIRNLPEDVHRALRVRAALHGRSTEAEVREILASAVKPEARVRMGDALAALGREIGITDDDLETMIQTRDKTPAEP
PRFE

Download         Length: 255 bp

>AT223131 NZ_CP118537:231140-231427 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAGTCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References