Detailed information of TA system TA223130

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 451649..452412
• Replicon: chromosome
• Accession: NZ_CP086370
• Organism: Massilia sp. HC52

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: KT882_RS01995
• Protein ID: WP_161070193.1
• Coordinates: 451649..452143 (-)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: -
• Locus tag: KT882_RS02000
• Protein ID: WP_228894217.1
• Coordinates: 452140..452412 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KT882_RS01965	447753..448169	-	417	WP_161070199.1	CopG family transcriptional regulator	-
KT882_RS01970	448284..448655	+	372	WP_228894212.1	VOC family protein	-
KT882_RS01975	448687..448902	+	216	WP_228894213.1	DUF1289 domain-containing protein	-
KT882_RS01980	448911..449822	+	912	WP_228894214.1	MBL fold metallo-hydrolase	-
KT882_RS01985	449914..450867	+	954	WP_228894215.1	nitronate monooxygenase family protein	-
KT882_RS01990	450925..451659	+	735	WP_228894216.1	transporter substrate-binding domain-containing protein	-
KT882_RS01995	451649..452143	-	495	WP_161070193.1	GNAT family N-acetyltransferase	Toxin
KT882_RS02000	452140..452412	-	273	WP_228894217.1	DUF1778 domain-containing protein	Antitoxin
KT882_RS02005	452497..453099	-	603	WP_228894218.1	transcriptional regulator	-
KT882_RS02010	453131..453709	-	579	WP_161070190.1	hypoxanthine-guanine phosphoribosyltransferase	-
KT882_RS02015	453802..455055	-	1254	WP_228896829.1	AMP-binding protein	-
KT882_RS02020	455055..455405	-	351	WP_228894219.1	MmcQ/YjbR family DNA-binding protein	-
KT882_RS02025	455413..456240	-	828	WP_161070188.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (31-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-80)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 17858.66 Da
• Isoelectric Point: 10.0221

>T223130 WP_161070193.1 NZ_CP086370:c452143-451649 [Massilia sp. HC52]
MSLRLTPPVPLAATHLLDGFECGEAALDGWLKRRAMANQVSNASRTFVVADQDGHVYGYYAMAAGAVAHQMATGSVRRNM
PDPVPVLVLARLAVDRRAQGMKIGAALLQDAVNRAVTVSRHAGVRALLVHALNDTAKKFYEHYGFQESPQHPMTLMLRLN
AVKE

Nucleotide

• Length: 495 bp

>T223130 NZ_CP118536:4638705-4639016 [Salmonella enterica subsp. enterica serovar Typhi]
GTGCATGTTATCAGCCGAAAACTGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCGCTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10108.67 Da
• Isoelectric Point: 6.4587

>AT223130 WP_228894217.1 NZ_CP086370:c452412-452140 [Massilia sp. HC52]
MRDAAINLRALPEQRDLIDRAANLLGKNRSDFMLEAACEKAQEVVLDQVFFSMDTDKFKHFNALLDAPPSHNPGLERLMA
VAAPWITAKK

Nucleotide

• Length: 273 bp

>AT223130 NZ_CP118536:4639013-4639459 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG