Detailed information of TA system TA022313

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipB(antitoxin)
• Location: 411584..412044
• Replicon: chromosome
• Accession: NC_009665
• Organism: Shewanella baltica OS185

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A9KXZ5
• Locus tag: SHEW185_RS01895
• Protein ID: WP_011982214.1
• Coordinates: 411865..412044 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: SHEW185_RS01890
• Protein ID: WP_006079858.1
• Coordinates: 411584..411865 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SHEW185_RS01870	407336..408232	-	897	WP_011982211.1	LysR family transcriptional regulator	-
SHEW185_RS01875	408472..409209	+	738	WP_011982212.1	pyrimidine 5'-nucleotidase	-
SHEW185_RS01880	409244..409882	-	639	WP_006086643.1	multidrug MFS transporter	-
SHEW185_RS01885	410064..411197	+	1134	WP_011982213.1	hypothetical protein	-
SHEW185_RS01890	411584..411865	+	282	WP_006079858.1	helix-turn-helix domain-containing protein	Antitoxin
SHEW185_RS01895	411865..412044	+	180	WP_011982214.1	HipA N-terminal domain-containing protein	Toxin
SHEW185_RS01900	412102..412965	-	864	WP_006079861.1	YicC family protein	-
SHEW185_RS01905	413503..414216	+	714	WP_006079862.1	ribonuclease PH	-
SHEW185_RS01910	414393..415034	+	642	WP_006086671.1	orotate phosphoribosyltransferase	-
SHEW185_RS01915	415261..415911	-	651	WP_006079864.1	GTP cyclohydrolase I FolE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-52)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6576.72 Da
• Isoelectric Point: 10.1058

>T22313 WP_011982214.1 NC_009665:411865-412044 [Shewanella baltica OS185]
MAVLDVYMNGYLVRELTKSSTGSHQFAYAQQWLAIPGSRPISLSMLLRKQACKGFFPAP

Nucleotide

• Length: 180 bp

>T22313 NC_009665:411865-412044 [Shewanella baltica OS185]
ATGGCAGTGCTTGATGTTTATATGAATGGCTACCTTGTGCGTGAATTGACCAAATCATCCACAGGCTCTCATCAGTTTGC
GTATGCCCAGCAATGGCTAGCTATACCCGGTAGTCGCCCAATTTCTTTGTCTATGCTGCTACGCAAGCAAGCTTGTAAAG
GTTTTTTTCCTGCGCCATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10697.12 Da
• Isoelectric Point: 7.0147

>AT22313 WP_006079858.1 NC_009665:411584-411865 [Shewanella baltica OS185]
MKVTNAKQLSTYLKDARLNAQLSQSKVASKVGIRQDTVSSFELNPDSTKLETLFKILSALNLELDIKVRNPQLVDERRHD
NATVPEQEWKEEW

Nucleotide

• Length: 282 bp

>AT22313 NC_009665:411584-411865 [Shewanella baltica OS185]
ATGAAGGTGACCAACGCAAAGCAGTTGAGTACGTATCTAAAAGATGCGCGGCTGAACGCGCAGCTCTCGCAAAGCAAGGT
GGCGAGCAAGGTAGGTATTCGCCAGGATACCGTTTCAAGCTTTGAGTTGAACCCGGATTCGACCAAATTAGAAACGCTGT
TTAAGATCCTTTCTGCATTAAACCTAGAGCTAGATATAAAGGTTCGGAATCCACAGCTGGTGGATGAGCGCCGCCATGAT
AACGCCACAGTGCCTGAGCAAGAATGGAAGGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A9KXZ5