Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 210930..211507 Replicon chromosome
Accession NZ_CP086370
Organism Massilia sp. HC52

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag KT882_RS00840 Protein ID WP_228894122.1
Coordinates 211169..211507 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag KT882_RS00835 Protein ID WP_161070385.1
Coordinates 210930..211172 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KT882_RS00805 206725..207066 - 342 WP_161070391.1 STAS domain-containing protein -
KT882_RS00810 207081..207743 - 663 WP_161070390.1 ABC transporter substrate-binding protein -
KT882_RS00815 207776..208591 - 816 WP_161070389.1 VacJ family lipoprotein -
KT882_RS00820 208593..209063 - 471 WP_161070388.1 outer membrane lipid asymmetry maintenance protein MlaD -
KT882_RS00825 209108..209890 - 783 WP_161070387.1 lipid asymmetry maintenance ABC transporter permease subunit MlaE -
KT882_RS00830 209887..210690 - 804 WP_161070386.1 ABC transporter ATP-binding protein -
KT882_RS00835 210930..211172 + 243 WP_161070385.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KT882_RS00840 211169..211507 + 339 WP_228894122.1 endoribonuclease MazF Toxin
KT882_RS00845 211574..213037 - 1464 WP_161070384.1 glutamate synthase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-111)

Antitoxin

Antitoxin PemI-like

(5-79)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12034.90 Da        Isoelectric Point: 10.1386

>T223129 WP_228894122.1 NZ_CP086370:211169-211507 [Massilia sp. HC52]
VTGTAYVPDEGDIVWMNFTPQSGHEQAGRRPAVVLSPKSYNLRAGLLVCVPVSQIKGYPFEVALTGMGATGAALADQVKN
VDWQTRKAEHKGKASAAEMGQIRAKIKTLLRL

Download         Length: 339 bp

>T223129 NZ_CP118536:c4637243-4636869 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGTCAAAGGGTCTGCGCTTTTTGATACCAATATCCTCATCGACCTGTTTAGCGGTCGAATTGAAGCGAAACATGCGCT
GGAAGCGTATCCGCCACAAAATGCGATTAGCCTTATCACATGGATGGAAGTGATGGTGGGTGCTAAGAAATATCATCAGG
AAAACCGCACGCGCATTGCATTAAGTGCGTTCAATATTATTGGCGTAACACAGGAAATCGCGGAACGAAGCGTCATTGTC
AGGCAGGAGTATGGCATGAAACTCCCGGATGCGATCATTCTGGCCACTGCACAAGTCCATCGTTGTGAGCTTGTGACGCG
CAATACAAAAGACTTTGCCGATATTCCGGGAGTGATCACGCCGTATCACTTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8584.82 Da        Isoelectric Point: 4.7318

>AT223129 WP_161070385.1 NZ_CP086370:210930-211172 [Massilia sp. HC52]
MARQVLKKWGNSTAVRLPAAVMEAANLAVDQAVDVRAEHGRVIIEAAAPIYLLDDLLEGITPENRHGEVDTGAPQGKELL

Download         Length: 243 bp

>AT223129 NZ_CP118536:c4637485-4637243 [Salmonella enterica subsp. enterica serovar Typhi]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGACGATGTGATTAAACGGCTTGACGATCTCAAGGT
GCAACGCAACCTACCTCGTGCAGAACTCTTGCGGGAGGCCGTTGAGCAGTATCTGGAAAGACAGGATCGGGCTGAGACCA
CAATTTCGAAAGCATTGGGGCTCTGGCAAGGCTGTGAGGAAGATGGCGTTGAATACCAACGTAAACTTCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References