Detailed information of TA system TA223121

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3395688..3396348
• Replicon: chromosome
• Accession: NZ_CP086369
• Organism: Pectobacterium versatile strain A73-S18-O15

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LLE50_RS15400
• Protein ID: WP_103861404.1
• Coordinates: 3395935..3396348 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A1V2R9A9
• Locus tag: LLE50_RS15395
• Protein ID: WP_039355397.1
• Coordinates: 3395688..3395954 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLE50_RS15375 (LLE50_15370)	3391590..3392594	-	1005	WP_130621905.1	substrate-binding domain-containing protein	-
LLE50_RS15380 (LLE50_15375)	3392649..3393257	-	609	WP_095701613.1	HD domain-containing protein	-
LLE50_RS15385 (LLE50_15380)	3393536..3394183	+	648	WP_039539856.1	hemolysin III family protein	-
LLE50_RS15390 (LLE50_15385)	3394451..3395452	-	1002	WP_103971792.1	tRNA-modifying protein YgfZ	-
LLE50_RS15395 (LLE50_15390)	3395688..3395954	+	267	WP_039355397.1	FAD assembly factor SdhE	Antitoxin
LLE50_RS15400 (LLE50_15395)	3395935..3396348	+	414	WP_103861404.1	protein YgfX	Toxin
LLE50_RS15405 (LLE50_15400)	3396417..3397352	+	936	WP_130621906.1	23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF	-
LLE50_RS15410 (LLE50_15405)	3397418..3397741	-	324	WP_103861402.1	hypothetical protein	-
LLE50_RS15415 (LLE50_15410)	3397770..3398288	-	519	WP_103861401.1	flavodoxin FldB	-
LLE50_RS15420 (LLE50_15415)	3398630..3399016	-	387	WP_103861400.1	thioesterase family protein	-
LLE50_RS15425 (LLE50_15420)	3399241..3400569	-	1329	WP_103861399.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16359.31 Da
• Isoelectric Point: 10.7911

>T223121 WP_103861404.1 NZ_CP086369:3395935-3396348 [Pectobacterium versatile]
VAQWRCDLRVSWRMQLLSLVVHGLLVLFILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNAKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Nucleotide

• Length: 414 bp

>T223121 NZ_CP118536:c806762-806361 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCCTTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGACAG
GACTGGACGCTCTTGCGTCCTCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
AG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10506.99 Da
• Isoelectric Point: 6.2223

>AT223121 WP_039355397.1 NZ_CP086369:3395688-3395954 [Pectobacterium versatile]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPKDGELKRMISLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT223121 NZ_CP118536:c807009-806743 [Salmonella enterica subsp. enterica serovar Typhi]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A1V2R9A9