Detailed information of TA system TA223119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3154979..3155562
• Replicon: chromosome
• Accession: NZ_CP086369
• Organism: Pectobacterium versatile strain A73-S18-O15

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LLE50_RS14295
• Protein ID: WP_130621282.1
• Coordinates: 3155257..3155562 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7V8PT23
• Locus tag: LLE50_RS14290
• Protein ID: WP_010296210.1
• Coordinates: 3154979..3155269 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LLE50_RS14270 (LLE50_14265)	3150113..3151375	-	1263	WP_103861534.1	L-rhamnose isomerase	-
LLE50_RS14275 (LLE50_14270)	3151372..3152862	-	1491	WP_119158967.1	rhamnulokinase	-
LLE50_RS14280 (LLE50_14275)	3153199..3154038	+	840	WP_103861532.1	HTH-type transcriptional activator RhaS	-
LLE50_RS14285 (LLE50_14280)	3154063..3154917	+	855	WP_039507370.1	helix-turn-helix domain-containing protein	-
LLE50_RS14290 (LLE50_14285)	3154979..3155269	+	291	WP_010296210.1	ribbon-helix-helix protein, CopG family	Antitoxin
LLE50_RS14295 (LLE50_14290)	3155257..3155562	+	306	WP_130621282.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LLE50_RS14300 (LLE50_14295)	3155682..3157388	-	1707	WP_130621281.1	ABC transporter ATP-binding protein	-
LLE50_RS14305 (LLE50_14300)	3157385..3158251	-	867	WP_125232223.1	ABC transporter permease	-
LLE50_RS14310 (LLE50_14305)	3158244..3159203	-	960	WP_029367586.1	ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11588.49 Da
• Isoelectric Point: 9.8325

>T223119 WP_130621282.1 NZ_CP086369:3155257-3155562 [Pectobacterium versatile]
MPQVIVSERARRDLQRLQDFLKNKNALAAKKAAEVLIRGIRQLEALPNIGRPVEHLPLEYQELVIEFGSSGYVMLYRHDE
LIGRVVILTVKHQKEAGYQNP

Nucleotide

• Length: 306 bp

>T223119 NZ_CP118536:205030-205515 [Salmonella enterica subsp. enterica serovar Typhi]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGACGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 11064.13 Da
• Isoelectric Point: 4.7692

>AT223119 WP_010296210.1 NZ_CP086369:3154979-3155269 [Pectobacterium versatile]
MADTTRQTTTLRIDQDIKERLKTLADDRNSSAHALMLEAIAEYVEREEKRSQYRKEALAAWEDYQDTGKHITADETVTWL
ESWGSGHEQDAPACHK

Nucleotide

• Length: 291 bp

>AT223119 NZ_CP118536:204755-205042 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAGTCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCGGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A7V8PT23